ArticleOrganic letters2015
Modular synthesis of cell-permeating 2-ketoglutarate esters.
Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Development and First-in-Human Translation of Hyperpolarized [1-Sensors (Basel, Switzerland) · 2026Article
- Analogue-Sensitive Inhibition of Histone Demethylases Uncovers Member-Specific Function in Ribosomal Protein Synthesis.Journal of the American Chemical Society · 2025Article
- Simple Esterification of [1-ACS chemical biology · 2021Article
- Article
- Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters.Nature communications · 2021Article
- Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase.Chemical science · 2020Article
- Epigenetic regulation by endogenous metabolite pharmacology.Current opinion in chemical biology · 2019Review
- Photoinducible Oncometabolite Detection.Chembiochem : a European journal of chemical biology · 2019Article
- Bioorthogonal oncometabolite ligation.Methods in enzymology · 2019Article
- Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases.Journal of the American Chemical Society · 2018Article
- Pot-Economy Autooxidative Condensation of 2-Aryl-2-lithio-1,3-dithianes.The Journal of organic chemistry · 2018Article
- Bioorthogonal pro-metabolites for profiling short chain fatty acylation.Chemical science · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cell-permeating esters of 2-ketoglutarate (2-KG) have been synthesized through a convergent sequence from two modules in two and three steps, respectively. This route provides access to a full series of mono- and disubstituted 2-KG esters, enabling us to define the effect of regioisomeric masking on metabolite release and antihypoxic activity in cell-based assays. In addition to providing insight into the biological activity of cell permeable 2-KG esters, the straightforward and modular nature of this synthetic route may prove useful for the development of next-generation 2-KG analogues for diagnostic and therapeutic applications.
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