ArticlePLoS biology2015
Extracellular adenosine mediates a systemic metabolic switch during immune response.
Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 171 citations in OpenAlex.
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- Horizontal gene transfer rivals gene duplication as a source of anti-parasitoid immune innovation in the Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- Coevolution of host resistance and pathogen exploitation in a propagule-mediated infection model.PLoS computational biology · 2026Article
- Macrophage-mediated nutrient recycling: evolutionary insights into the metabolic role of professional phagocytes.Frontiers in immunology · 2026Review
- Muscling in on immunity: the role of muscle in the insect immune response, demonstrating the value of a whole organism perspective.Frontiers in immunology · 2026Review
- Summer-form susceptible, winter-form resistant: differential susceptibility ofFrontiers in cellular and infection microbiology · 2026Article
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- Nymphal diets boost adults' immunity via strengthened constitutive immunity and metabolic capacity in Adelphocoris suturalis.Communications biology · 2025Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- ThebioRxiv : the preprint server for biology · 2025Article
- Remote control of AMPK via extracellular adenosine controls tissue growth.Nature cell biology · 2025Article
- Phycobiliprotein Extract fromMarine drugs · 2025Article
- Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3.PLoS genetics · 2025Article
- Article
- Insect immunity in the Anthropocene.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Effects of Microbes on Insect Host Physiology and Behavior Mediated by the Host Immune System.Insects · 2025Review
- Proteomic analysis unveils host-parasite interactions in Aedes togoi infected with Dirofilaria immitis and Brugia pahangi.PloS one · 2025Article
- QTL Mapping-Based Identification of Visceral White-Nodules Disease Resistance Genes inInternational journal of molecular sciences · 2024Article
- Glycolytic Disruption Triggers Interorgan Signaling to Nonautonomously RestrictbioRxiv : the preprint server for biology · 2024Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune defense is energetically costly, and thus an effective response requires metabolic adaptation of the organism to reallocate energy from storage, growth, and development towards the immune system. We employ the natural infection of Drosophila with a parasitoid wasp to study energy regulation during immune response. To combat the invasion, the host must produce specialized immune cells (lamellocytes) that destroy the parasitoid egg. We show that a significant portion of nutrients are allocated to differentiating lamellocytes when they would otherwise be used for development. This systemic metabolic switch is mediated by extracellular adenosine released from immune cells. The switch is crucial for an effective immune response. Preventing adenosine transport from immune cells or blocking adenosine receptor precludes the metabolic switch and the deceleration of development, dramatically reducing host resistance. Adenosine thus serves as a signal that the "selfish" immune cells send during infection to secure more energy at the expense of other tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.