ArticleCellular & molecular immunology2016
Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin.
Article in Cellular & molecular immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Construction of subunit vaccine by fusingFrontiers in veterinary science · 2026Article
- Article
- Nanomaterial-assisted oncolytic bacteria in solid tumor diagnosis and therapeutics.Bioengineering & translational medicine · 2024Review
- A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages.Frontiers in immunology · 2023Article
- Flagellin Improves the Immune Response of an Infectious Bursal Disease Virus (IBDV) Subunit Vaccine.Vaccines · 2022Article
- Different serotypes of Escherichia coli flagellin exert identical adjuvant effects.BMC veterinary research · 2022Article
- Inflammasomes and adaptive immune responses.Nature immunology · 2021Review
- Techniques to Study Inflammasome Activation and Inhibition by Small Molecules.Molecules (Basel, Switzerland) · 2021Review
- TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8Immunology · 2020Article
- Article
- NLRC4 Mutation in flagellin-derived peptide CBLB502 ligand-binding domain reduces the inflammatory response but not radioprotective activity.Journal of radiation research · 2019Article
- Enhancement of antigen-specific humoral immune responses and protein solubility through conjugation of bacterial flagellin,Journal of veterinary science · 2019Article
- The N-terminal D1 domain of Treponema pallidum flagellin binding to TLR5 is required but not sufficient in activation of TLR5.Journal of cellular and molecular medicine · 2019Article
- Adaptive Immunity Induces Tolerance to Flagellin by Attenuating TLR5 and NLRC4-Mediated Innate Immune Responses.Frontiers in cellular and infection microbiology · 2019Article
- Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.The Journal of allergy and clinical immunology · 2018Article
- Amino acids 89-96 of Salmonella flagellin: a key site for its adjuvant effect independent of the TLR5 signaling pathway.Cellular & molecular immunology · 2017Article
- Flagellin: a unique microbe-associated molecular pattern and a multi-faceted immunomodulator.Cellular & molecular immunology · 2017Article
- Flagellin-rPAc vaccine inhibits biofilm formation but not proliferation of S. mutans.Human vaccines & immunotherapeutics · 2016Article
- Cellular and molecular regulation of innate inflammatory responses.Cellular & molecular immunology · 2016Review
- Current Concepts and Controversies in Innate Immunity of Cystic Fibrosis Lung Disease.Journal of innate immunity · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial flagellin is a unique pathogen-associated molecular pattern (PAMP), which can be recognized by surface localized Toll-like receptor 5 (TLR5) and the cytosolic NOD-like receptor (NLR) protein 4 (NLRC4) receptors. Activation of the TLR5 and/or NLRC4 signaling pathways by flagellin and the resulting immune responses play important roles in anti-bacterial immunity. However, it remains unclear how the dual activities of flagellin that activate the TLR5 and/or NLRC4 signaling pathways orchestrate the immune responses. In this study, we assessed the effects of flagellin and its mutants lacking the ability to activate TLR5 and NLRC4 alone or in combination on the adaptive immune responses against flagellin. Flagellin that was unable to activate NLRC4 induced a significantly higher antibody response than did wild-type flagellin. The increased antibody response could be eliminated when macrophages were depleted in vivo. The activation of NLRC4 by flagellin downregulated the flagellin-induced and TLR5-mediated immune responses against flagellin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.