Evidence map›Paper›PMID 25914807›Full record

ArticleRSC advances

Acid-responsive nanospheres from an asparagine-derived amphiphile.

Adelphe M Mfuh, Mathew P D Mahindaratne, Audrey E Yñigez-Gutierrez, Juan R Ramos Dominguez, Jefferson T Bedell, Carlos D Garcia, George R Negrete

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adelphe M MfuhDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Mathew P D MahindaratneTexas A&M University-San Antonio, One University Way, San Antonio, TX 78224, USA.
Audrey E Yñigez-GutierrezDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Juan R Ramos DominguezDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Jefferson T BedellDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Carlos D GarciaDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
George R NegreteDepartment of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
STRUCTURAL VISUALIZATION IN BIOINFORMATICSG12RR013646 · NCRR · UNIVERSITY OF TEXAS SAN ANTONIO · PI ZHANG, JI · 1998 to 2011
$19.6M
RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
NCRR NIH HHS G12 RR013646NIGMS NIH HHS R25 GM060655NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

Identifiers

PMID25914807
PMCPMC4407701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.