Evidence map›Paper›PMID 25914788›Full record

ArticleWorld journal of cardiology2015

Helicobacter pylori vs coronary heart disease - searching for connections.

Magdalena Chmiela, Adrian Gajewski, Karolina Rudnicka

Open access · hybridAbstract read
In one paragraph

Article in World journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022
    Pooled it
  2. An Updated Meta-Analysis of the Relationship BetweenFrontiers in cardiovascular medicine · 2022
    Pooled it
  3. Glucolipid Metabolic Disorders andInternational journal of endocrinology · 2026
    Review
  4. Metabolism open · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. The influence ofFrontiers in cellular and infection microbiology · 2024
    Article
  9. Frontiers in microbiology · 2024
    Review
  10. Antibiotics (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. BioMed research international · 2022
    Review
  16. International journal of molecular sciences · 2021
    Article
  17. Article
  18. Dyslipidemia and Associated Factors Among Patients Suspected to HaveInternational journal of general medicine · 2020
    Article
  19. Anti-Glycan Autoantibodies Induced byFrontiers in immunology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Magdalena ChmielaMagdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
Adrian GajewskiMagdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
Karolina RudnickaMagdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
University of Magdalena · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this review, we discussed the findings and concepts underlying the potential role of Helicobacter pylori (H. pylori) infections in the initiation, development or persistence of atherosclerosis and coronary heart disease (CHD). This Gram-negative bacterium was described by Marshall and Warren in 1984. The majority of infected subjects carries and transmits H. pylori with no symptoms; however, in some individuals these bacteria may cause peptic ulcers, and even gastric cancers. The widespread prevalence of H. pylori infections and the fact that frequently they remain asymptomatic may suggest that, similarly to intestinal microflora, H. pylori may deliver antigens that stimulate not only local, but also systemic inflammatory response. Recently, possible association between H. pylori infection and extragastric disorders has been suggested. Knowledge on the etiology of atherosclerosis together with current findings in the area of H. pylori infections constitute the background for the newly proposed hypothesis that those two processes may be related. Many research studies confirm the indirect association between the prevalence of H. pylori and the occurrence of CHD. According to majority of findings the involvement of H. pylori in this process is based on the chronic inflammation which might facilitate the CHD-related pathologies. It needs to be elucidated, if the infection initiate or just accelerate the formation of atheromatous plaque.

Indexed as

Coronary heart diseaseHelicobacter pyloriInflammationLipopolysaccharideMicrobiota

Identifiers

PMID25914788
PMCPMC4404374
OpenAlexW349046371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.