Evidence map›Paper›PMID 25914344›Full record

ArticleHead & neck2016

Matted nodes: High distant-metastasis risk and a potential indication for intensification of systemic therapy in human papillomavirus-related oropharyngeal cancer.

Jeffrey M Vainshtein, Matthew E Spector, Mohannad Ibrahim, Carol R Bradford, Gregory T Wolf, Matthew H Stenmark, Francis P Worden, Jonathan B McHugh, Mark E Prince, Thomas Carey and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
  2. Initial Feasibility and Acute Toxicity Outcomes From a Phase 2 Trial ofInternational journal of radiation oncology, biology, physics · 2023
    Trial
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  6. Predictive Value ofCancers · 2022
    Article
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  12. CT and FDG-PET radiologic biomarkers in p16+ oropharyngeal squamous cell carcinoma patients treated with definitive chemoradiotherapy.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Article
  13. Metastatic disease in head & neck oncology.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020
    Review
  14. Article
  15. VolumetricHead & neck · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jeffrey M VainshteinDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Matthew E SpectorDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Mohannad IbrahimDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.
Carol R BradfordDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.
Gregory T WolfDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Matthew H StenmarkDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
Francis P WordenDivision of Hematology Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Jonathan B McHughDepartment of Pathology, University of Michigan, Ann Arbor, Michigan.
Mark E PrinceDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Thomas CareyDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Douglas B ChepehaDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Avraham EisbruchDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.
University of Michigan–Ann Arbor · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOLF, GREGORY T · 2002 to 2013
$25.3M
NCATS NIH HHS UL1 TR000433NCI NIH HHS P50 CA097248
6 · The paper itself

Abstract

backgroundThe purpose of this study was to determine whether matted nodes uniquely identify patients with human papillomavirus (HPV)-positive oropharyngeal cancer at disproportionately high distant failure risk who may benefit from intensified systemic therapy.

methodsOne hundred seventy-eight patients with stage III/IV HPV-positive oropharyngeal cancer who completed definitive chemoradiotherapy were stratified by risk group (low-risk = T1-3/N0-2c/<10 pack-years; intermediate-risk = T1-3/N0-2c/≥10 pack-years; and high-risk = T4 or N3). Prognostic impact of matted nodes was assessed.

resultsAt the 52-month median follow-up, event rates with and without matted nodes were: locoregional failure: 23.3% versus 12.8% (p = .16), distant failure: 50.0% versus 1.4% (p < .01), any failure: 73.3% versus 14.2% (p < .01); cause-specific mortality: 56.7% versus 5.4% (p < .01), and death: 56.7% versus 13.5% (p < .01). In multivariate analyses, including risk group and individual risk factors, matted nodes were the strongest predictor for all endpoints except locoregional failure. Among patients without matted nodes, risk-group discriminated locoregional failure (at 3 years: low-risk = 2.0%; intermediate-risk = 14.4%; and high-risk = 24.2%; p < .01), but not distant failure (low-risk = 0.0%; intermediate-risk = 2.1%; and high-risk = 3.8%; p = .53).

conclusionMatted nodes portended dramatically increased distant failure and death risks in HPV-positive oropharyngeal cancer, identifying a candidate population for consideration of chemo-intensification. © 2015 Wiley Periodicals, Inc. Head Neck 38: E805-E814, 2016.

Indexed as

AdultAgedChemoradiotherapyFemaleHumansLymph NodesMaleMiddle AgedNeoplasm MetastasisNeoplasm StagingOropharyngeal NeoplasmsPapillomaviridaePapillomavirus InfectionsPrognosisRetrospective StudiesRisk Factorsdistant metastaseshuman papillomavirusmatted nodesoropharyngeal cancer

Identifiers

PMID25914344
PMCPMC4624049
OpenAlexW1909224217

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.