ArticleJournal of magnetic resonance imaging : JMRI2015
Comparing tract-based spatial statistics and manual region-of-Interest labeling as diffusion analysis methods to detect white matter abnormalities in infants with hypoxic-Ischemic encephalopathy.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Graph-Based White Matter Tractometry: Methods, Applications, and the Path to Validation.Neuroinformatics · 2026Review
- Evaluation of white matter integrity by diffusion tensor imaging in the deficiencies of vitamin B12 and folate in older patients.The British journal of radiology · 2023Article
- Microstructural Alterations in Projection and Association Fibers in Neonatal Hypoxia-Ischemia.Journal of magnetic resonance imaging : JMRI · 2023Article
- Functional MRI and Diffusion Tensor Imaging in Migraine: A Review of Migraine Functional and White Matter Microstructural Changes.Journal of central nervous system disease · 2023Review
- Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic-ischemic encephalopathy.Frontiers in neuroscience · 2022Article
- Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly.Neuroradiology · 2020Article
- Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study.Journal of child neurology · 2019Article
- Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome.Brain imaging and behavior · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo compare manual region of interest (ROI) labeling and tract-based spatial statistics (TBSS) by their ability to detect group-wise differences in fractional anisotropy (FA) in the neonatal brain. MATERIALS AND
methodsDiffusion-weighted data were obtained for nine infants with hypoxic-ischemic encephalopathy (HIE) (six males, three females; gestational age [GA] range, 36-40 weeks; mean GA, 37.8 weeks) and 11 healthy-control infants (10 males, 1 female; GA range, 36-40 weeks; mean GA, 38.4 weeks) at 3T. For manual ROI labeling, ROIs were drawn freehand for each subject in eight, clinically relevant brain regions. For TBSS, all FA data underwent an optimized, automated protocol for neonates. Each method was evaluated for detection of decreased FA in HIE infants, sensitivity, specificity, and variability.
resultsFA values from manual ROI and TBSS were strongly correlated (r = 0.94, P < 0.0001). Both methods found decreased FA in most ROIs for HIE infants. There was no significant interaction between method and group, indicating a similar ability to detect FA differences (F(1,19) = 0.599, P = 0.449). Sensitivity (manual: 0.709, TBSS: 0.694, 95% CI [-0.136, 0.163], P = 0.856), specificity (manual and TBSS: 0.716, 95% CI [-0.133, 0.133], P = 1), and standard error (manual: 0.009, TBSS: 0.007) were comparable.
conclusionManual ROI labeling and TBSS are comparable methods of diffusion analysis to detect group differences in FA in the neonatal brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.