ReviewDrug safety2015
Oral anticoagulants and risk of nephropathy.
Review in Drug safety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Use of non-vitamin K antagonists oral anticoagulants in atrial fibrillation patients on dialysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Macroscopic hematuria-associated severe acute kidney injury triggered by kidney stone formation in a patient with thin basement membrane and no history of microscopic hematuria.CEN case reports · 2025Article
- Dabigatran-related Nephropathy Complicated by Tubulointerstitial Nephritis in a Patient with a Normal Renal Function and Undiagnosed IgA Nephropathy.Internal medicine (Tokyo, Japan) · 2024Article
- Practical approaches to building up a cardiorenal clinic.Clinical kidney journal · 2023Review
- Dabigatran-Induced Nephropathy and Gastrointestinal Bleeding and Its Successful Treatment with Idarucizumab: A Case Report.Hospital pharmacy · 2022Article
- Review
- The change of renal functions after nonvitamin K oral anticoagulants in patients with atrial fibrillation.International journal of cardiology. Heart & vasculature · 2021Article
- Dabigatran-induced anticoagulant-related nephropathy with undiagnosed IgA nephropathy in a patient with normal baseline renal function.CEN case reports · 2019Article
- Anticoagulant-Related Nephropathy: It's the Real McCoy.Clinical journal of the American Society of Nephrology : CJASN · 2019Article
- Anticoagulant-related nephropathy: systematic review and meta-analysis.Clinical kidney journal · 2019Article
- Exposure to vitamin k antagonists and kidney function decline in patients with atrial fibrillation and chronic kidney disease.Research and practice in thrombosis and haemostasis · 2019Article
- Anticoagulant-Related Nephropathy.Journal of the American Society of Nephrology : JASN · 2018Review
- Renal function in patients with mechanical prosthetic valves : Long-term effects of anticoagulation and over-anticoagulation with warfarin.Wiener klinische Wochenschrift · 2018Article
- Anticoagulant Related Nephropathy Induced by Dabigatran.Case reports in nephrology · 2018Article
- Review
- Warfarin-related nephropathy in a patient with renal pelvic cancer.Clinical nephrology. Case studies · 2017Article
- Bioptically Proven "Anticoagulation-Related Nephropathy" Induced by Dual Antiplatelet Therapy.Case reports in nephrology and dialysisArticle
- Oral Anticoagulant-Related Nephropathy: A New Cause for an Old Entity.Indian journal of nephrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticoagulant-related nephropathy, a recently recognized entity, manifests as unexplained acute kidney injury in the setting of excessive anticoagulation with oral agents. Histologic findings in warfarin-related nephropathy include glomerular hemorrhage and renal tubular obstruction by red blood cells. Affected patients are at increased risk of mortality as well as irreversible kidney injury. Patients with chronic kidney disease are particularly vulnerable to this complication. Similar case reports of anticoagulant-related nephropathy have been linked to the more novel oral anticoagulant, dabigatran. Anticoagulant-related nephropathy has been successfully reproduced in rat models. These animal models shed light on the pathogenesis of the disease including the potential role of direct thrombin and protease-activated receptor-1 inhibition. Warfarin and dabigatran also cause an increase in systolic blood pressure in rats, a risk factor for developing nephropathy. This article reviews the current evidence for anticoagulant-related nephropathy and provides data for the suggested possible mechanisms underlying this adverse effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.