ArticleHuman brain mapping2015
Amyotrophic lateral sclerosis affects cortical and subcortical activity underlying motor inhibition and action monitoring.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review.BMC neurology · 2016Pooled it
- Attentional Function in Patients With Amyotrophic Lateral Sclerosis is Moderated by Age and Education.Brain and behavior · 2026Article
- Disrupted Glucose Metabolism Covariance Network in Amyotrophic Lateral Sclerosis.CNS neuroscience & therapeutics · 2025Article
- Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients.Cardiovascular diabetology · 2023Article
- Motor cortex functional connectivity is associated with underlying neurochemistry in ALS.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Basal ganglia alterations in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2023Review
- Acute Colon Inflammation Triggers Primary Motor Cortex Glial Activation, Neuroinflammation, Neuronal Hyperexcitability, and Motor Coordination Deficits.International journal of molecular sciences · 2022Article
- Disruption of the white matter structural network and its correlation with baseline progression rate in patients with sporadic amyotrophic lateral sclerosis.Translational neurodegeneration · 2021Article
- Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis.Scientific reports · 2021Article
- Emerging Mechanisms Underpinning Neurophysiological Impairments inFrontiers in cellular neuroscience · 2021Review
- Imaging Cerebral Activity in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis.Frontiers in neuroscience · 2018Review
- Abnormal Functional Connectivity Density in Amyotrophic Lateral Sclerosis.Frontiers in aging neuroscience · 2018Article
- Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis.Human brain mapping · 2017Article
- Disrupted effective connectivity of the sensorimotor network in amyotrophic lateral sclerosis.Journal of neurology · 2016Article
- A Systematic Review and Meta-Analysis of the Functional MRI Investigation of Motor Neuron Disease.Frontiers in neurology · 2015Article
- Executive Dysfunctions and Event-Related Brain Potentials in Patients with Amyotrophic Lateral Sclerosis.Frontiers in aging neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by muscular atrophy, spasticity, and bulbar signs caused by loss of upper and lower motor neurons. Evidence suggests that ALS additionally affects other brain areas including premotor cortex and supplementary motor area. Here, we studied movement execution and inhibition in ALS patients using a stop-signal paradigm and functional magnetic resonance imaging. Seventeen ALS patients and 17 age-matched healthy controls performed a stop-signal task that required responding with a button press to a right- or left-pointing black arrow (go-stimuli). In stop-trials, a red arrow (stop-stimulus) was presented shortly after the black arrow indicating to withhold the prepared movement. Patients had by trend higher reaction times in go-trials but did not differ significantly in their inhibition performance. Patients showed stronger inhibition-related activity in inferior, superior, and middle frontal gyri as well as in putamen and pallidum. Error-related activity, conversely, was found to be stronger in healthy controls, particularly in the insula bilaterally. Patients also showed increased activity in the motor cortex during button presses. The results provide evidence for altered prefrontal and subcortical networks underlying motor execution, motor inhibition, and error monitoring in ALS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.