ArticleScientific reports2015
Fluorescence-Activated Cell Sorting Analysis of Heterotypic Cell-in-Cell Structures.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Tumor malignancy by genetic transfer between cells forming cell-in-cell structures.Cell death & disease · 2023Article
- Heterotypic cell-in-cell structures between cancer and NK cells are associated with enhanced anticancer drug resistance.iScience · 2022Article
- Molecular mechanisms underlying cell-in-cell formation: core machineries and beyond.Journal of molecular cell biology · 2021Article
- Cell-in-cell phenomenon: leukocyte engulfment by non-tumorigenic cells and cancer cell lines.BMC molecular and cell biology · 2021Article
- Smart diagnostics devices through artificial intelligence and mechanobiological approaches.3 Biotech · 2020Review
- Immune response activation following hyperthermic intraperitoneal chemotherapy for peritoneal metastases: A pilot study.World journal of clinical oncology · 2020Article
- Emperipolesis mediated by CD8Journal of cellular and molecular medicine · 2020Article
- Implication of cell-in-cell structures in the transmission of HIV to epithelial cells.Cell research · 2015Article
- Detecting cell-in-cell structures in human tumor samples by E-cadherin/CD68/CD45 triple staining.Oncotarget · 2015Article
- Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression.Scientific reports · 2015Article
- Cell-in-cell phenomenon: A New Paradigm in Life Sciences.Current molecular medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-in-cell structures (CICs), characterized by the presence of one or more viable cells inside another one, were recently found important player in development, immune homeostasis and tumorigenesis etc. Incompatible with ever-increasing interests on this unique phenomenon, reliable methods available for high throughput quantification and systemic investigation are lacking. Here, we report a flow cytometry-based method for rapid analysis and sorting of heterotypic CICs formed between lymphocytes and tumor cells. In this method, cells were labeled with fluorescent dyes for fluorescence-activated cell sorting (FACS) by flow cytometry, conditions for reducing cell doublets were optimized such that high purity (>95%) of CICs could be achieved. By taking advantage of this method, we analyzed CICs formation between different cell pairs, and found that factors from both internalized effector cells and engulfing target cells affect heterotypic CICs formation. Thus, flow cytometry-based FACS analysis would serve as a high throughput method to promote systemic researches on CICs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.