ArticleCurrent biology : CB2015
Intracranial Mapping of a Cortical Tinnitus System using Residual Inhibition.
Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03711630 (Impact of Meditation on Bothersome Tinnitus), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Meditation on Bothersome Tinnitus
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic architecture distinguishes tinnitus from hearing loss.Nature communications · 2024Pooled it
- Musical hallucinations and their relation with epilepsy.Journal of neurology · 2019Pooled it
- Tailor-made notched music training-induced residual inhibition in subjective tinnitus: resting-state EEG spectral power ratio evidence.Frontiers in neuroscience · 2026Trial
- Focal tDCS of auditory cortex in chronic tinnitus: A randomized controlled mechanistic trial.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Trial
- Reducing Tinnitus via Inhibitory Influence of the Sensorimotor System on Auditory Cortical Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prediction of acoustic tinnitus suppression using resting-state EEG via explainable AI approach.Scientific reports · 2025Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Cortical evoked activity is modulated by the sleep state in a ferret model of tinnitus. A cross-case study.PloS one · 2024Article
- Article
- A parahippocampal-sensory Bayesian vicious circle generates pain or tinnitus: a source-localized EEG study.Brain communications · 2023Article
- EEG spectral and microstate analysis originating residual inhibition of tinnitus induced by tailor-made notched music training.Frontiers in neuroscience · 2023Article
- Effect of sound therapy on whole scalp oscillatory brain activity and distress in chronic tinnitus patients.Frontiers in neuroscience · 2023Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Cortical Reorganization Following Psychoeducational Counselling and Residual Inhibition Therapy (RIT) in Individuals with Tinnitus.International archives of otorhinolaryngology · 2022Article
- Propagation and update of auditory perceptual priors through alpha and theta rhythms.The European journal of neuroscience · 2022Article
- Alterations in auditory brain stem response distinguish occasional and constant tinnitus.The Journal of clinical investigation · 2022Article
- Tinnitus: at a crossroad between phantom perception and sleep.Brain communications · 2022Review
- Higher Peripheral Inflammation Is Associated With Lower Orbitofrontal Gamma Power in Chronic Tinnitus.Frontiers in behavioral neuroscience · 2022Article
- Cortical oscillatory dysrhythmias in visual snow syndrome: a magnetoencephalography study.Brain communications · 2022Article
- [Research progress in auditory center plasticity and tinnitus mechanism].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Tinnitus can occur when damage to the peripheral auditory system leads to spontaneous brain activity that is interpreted as sound [1, 2]. Many abnormalities of brain activity are associated with tinnitus, but it is unclear how these relate to the phantom sound itself, as opposed to predisposing factors or secondary consequences [3]. Demonstrating "core" tinnitus correlates (processes that are both necessary and sufficient for tinnitus perception) requires high-precision recordings of neural activity combined with a behavioral paradigm in which the perception of tinnitus is manipulated and accurately reported by the subject. This has been previously impossible in animal and human research. Here we present extensive intracranial recordings from an awake, behaving tinnitus patient during short-term modifications in perceived tinnitus loudness after acoustic stimulation (residual inhibition) [4], permitting robust characterization of core tinnitus processes. As anticipated, we observed tinnitus-linked low-frequency (delta) oscillations [5-9], thought to be triggered by low-frequency bursting in the thalamus [10, 11]. Contrary to expectation, these delta changes extended far beyond circumscribed auditory cortical regions to encompass almost all of auditory cortex, plus large parts of temporal, parietal, sensorimotor, and limbic cortex. In discrete auditory, parahippocampal, and inferior parietal "hub" regions [12], these delta oscillations interacted with middle-frequency (alpha) and high-frequency (beta and gamma) activity, resulting in a coherent system of tightly coupled oscillations associated with high-level functions including memory and perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.