Evidence map›Paper›PMID 25913301›Full record

ArticleBiological psychology2015

Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.

Jeanne E Savage, Omari McMichael, Eugenia I Gorlin, Jessica R Beadel, Bethany Teachman, Vladimir I Vladimirov, John M Hettema, Roxann Roberson-Nay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Population Pharmacokinetics of Intranasal Amiloride in Healthy Volunteers.European journal of drug metabolism and pharmacokinetics · 2026
    Trial
  2. Article
  3. Article
  4. Hypoventilation Therapy Alleviates Panic by Repeated Induction of Dyspnea.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Review
  9. Article
  10. Panic Anxiety in Humans with Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016
    Article
  11. The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jeanne E SavageVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: savagej@vcu.edu.
Omari McMichaelVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Eugenia I GorlinDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Jessica R BeadelDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Bethany TeachmanDepartment of Psychology, University of Virginia, Charlottesville, VA, USA.
Vladimir I VladimirovVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, VA, USA; Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD, USA.
John M HettemaVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Roxann Roberson-NayVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Virginia Commonwealth University · USUniversity of Virginia · US

Funding

Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Genetic and Pathophysiologic Investigation of Panic Disorder TypologiesK01MH080953 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ROBERSON-NAY, ROXANN · 2008 to 2012
$814k
NCATS NIH HHS UL1 TR000058NCATS NIH HHS UL1TR000058NIMH NIH HHS K01 MH080953NIMH NIH HHS K01MH080953NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

Few replicable genetic variants have been identified in the etiology of heritable anxiety disorders such as panic disorder. Endophenotypic measures that have reduced heterogeneity may provide more powerful targets for gene identification. We assessed hypersensitivity to carbon dioxide (a reliable endophenotype of panic and anxiety) in 174 Caucasian college students, who were genotyped on 26 polymorphic markers from 11 genes previously associated with panic/anxiety. Individual trajectories of respiratory and subjective anxiety response to carbon dioxide were measured and tested for association with these genetic markers. One marker in the acid-sensing ion channel 1 (ASIC1) gene, rs1108923, had a significant association with respiratory rate. No genes had a significant association with subjective anxiety response. Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The use of endophenotypic markers is a promising avenue for gene identification in anxiety and other complex disorders.

Indexed as

EndophenotypesAcid Sensing Ion ChannelsAdultAnxietyAnxiety DisordersCarbon DioxideFemaleGenome-Wide Association StudyHumansLinear ModelsMaleRespiratory RateWhite PeopleYoung AdultAcid Sensing Ion ChannelsASIC1 protein, humanCarbon DioxideAcid-sensing ion channel 1Anxiety disordersASIC1Carbon dioxide hypersensitivityEndophenotypePanic disorder

Identifiers

PMID25913301
PMCPMC4516642
OpenAlexW2007132838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.