Evidence map›Paper›PMID 25913241›Full record

ArticleJournal of biomechanics2015

Heterogeneous growth-induced prestrain in the heart.

M Genet, M K Rausch, L C Lee, S Choy, X Zhao, G S Kassab, S Kozerke, J M Guccione, E Kuhl

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Volumetric growth of soft tissues evaluated in the current configuration.Biomechanics and modeling in mechanobiology · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021
    Review
  18. Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M GenetDepartment of Surgery, School of Medicine, University of California at San Francisco, USA; Institute for Biomedical Engineering, University and ETH Zürich, Switzerland. Electronic address: genet@biomed.ee.ethz.ch.
M K RauschDepartment of Mechanical Engineering, Stanford University, CA, USA.
L C LeeDepartment of Surgery, School of Medicine, University of California at San Francisco, USA; Department of Mechanical Engineering, Michigan State University, MI, USA.
S ChoyDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, USA.
X ZhaoDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, USA.
G S KassabDepartment of Mechanical Engineering, Michigan State University, MI, USA; Department of Cellular and Integrative Physiology, Indiana University-Purdue University Indianapolis, USA; Department of Surgery, Indiana University-Purdue University Indianapolis, USA.
S KozerkeInstitute for Biomedical Engineering, University and ETH Zürich, Switzerland.
J M GuccioneDepartment of Surgery, School of Medicine, University of California at San Francisco, USA.
E KuhlDepartment of Mechanical Engineering, Stanford University, CA, USA; Department of Bioengineering, Stanford University, CA, USA; Department of Cardiothoracic Surgery, Stanford University, CA, USA.

Funding

Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01-HL-077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS R01-HL-118627NHLBI NIH HHS U01 HL119578NHLBI NIH HHS U01-HL-119578
6 · The paper itself

Abstract

Even when entirely unloaded, biological structures are not stress-free, as shown by Y.C. Fung׳s seminal opening angle experiment on arteries and the left ventricle. As a result of this prestrain, subject-specific geometries extracted from medical imaging do not represent an unloaded reference configuration necessary for mechanical analysis, even if the structure is externally unloaded. Here we propose a new computational method to create physiological residual stress fields in subject-specific left ventricular geometries using the continuum theory of fictitious configurations combined with a fixed-point iteration. We also reproduced the opening angle experiment on four swine models, to characterize the range of normal opening angle values. The proposed method generates residual stress fields which can reliably reproduce the range of opening angles between 8.7±1.8 and 16.6±13.7 as measured experimentally. We demonstrate that including the effects of prestrain reduces the left ventricular stiffness by up to 40%, thus facilitating the ventricular filling, which has a significant impact on cardiac function. This method can improve the fidelity of subject-specific models to improve our understanding of cardiac diseases and to optimize treatment options.

Indexed as

Models, CardiovascularStress, MechanicalAnimalsArteriesBiomechanical PhenomenaFemaleFinite Element AnalysisHeart VentriclesHumansMaleModels, AnimalSwineVentricular FunctionFinite element methodFinite strainOpening anglePatient-specific modelingPrestrainResidual stress

Identifiers

PMID25913241
PMCPMC4492830

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.