ArticleThe Journal of allergy and clinical immunology2015
Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? A systematic review.The British journal of dermatology · 2020Pooled it
- Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease.Experimental & molecular medicine · 2024Review
- Asthma Exacerbations: Patient Features and Potential Long-Term Implications.Advances in experimental medicine and biology · 2023Article
- Asthma exacerbations: the Achilles heel of asthma care.Trends in molecular medicine · 2022Review
- Multidimensional molecular measurements-environment interaction analysis for disease outcomes.Biometrics · 2022Article
- Divergent Trends in the Prevalence of Children's Asthma, Rhinitis and Atopic Dermatitis and Environmental Influences in the Urban Setting of Zagreb, Croatia.Children (Basel, Switzerland) · 2022Article
- Th2 Cytokines (Interleukin-5 and -9) Polymorphism Affects the Response to Anti-TNF Treatment in Polish Patients with Ankylosing Spondylitis.International journal of molecular sciences · 2022Article
- Review
- Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- The Role of Defective Epithelial Barriers in Allergic Lung Disease and Asthma Development.Journal of asthma and allergy · 2022Review
- Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics.Cytokine & growth factor reviews · 2021Review
- The Predictive Role of Biomarkers and Genetics in Childhood Asthma Exacerbations.International journal of molecular sciences · 2021Review
- The Role ofCells · 2021Article
- Article
- Pulmonary Eosinophils at the Center of the Allergic Space-Time Continuum.Frontiers in immunology · 2021Review
- Addressing the risk domain in the long-term management of pediatric asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Review
- Colony-stimulating factor 1 and its receptor are new potential therapeutic targets for allergic asthma.Allergy · 2020Article
- Resolution of allergic asthma.Seminars in immunopathology · 2019Review
- Phthalates and asthma in children and adults: US NHANES 2007-2012.Environmental science and pollution research international · 2019Article
- House Dust Mite Allergy Under Changing Environments.Allergy, asthma & immunology research · 2019Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundGene-environment interaction studies using genome-wide association study data are often underpowered after adjustment for multiple comparisons. Differential gene expression in response to the exposure of interest can capture the most biologically relevant genes at the genome-wide level.
objectiveWe used differential genome-wide expression profiles from the Epidemiology of Home Allergens and Asthma birth cohort in response to Der f 1 allergen (sensitized vs nonsensitized) to inform a gene-environment study of dust mite exposure and asthma severity.
methodsPolymorphisms in differentially expressed genes were identified in genome-wide association study data from the Childhood Asthma Management Program, a clinical trial in childhood asthmatic patients. Home dust mite allergen levels (<10 or ≥10 μg/g dust) were assessed at baseline, and (≥1) severe asthma exacerbation (emergency department visit or hospitalization for asthma in the first trial year) served as the disease severity outcome. The Genetics of Asthma in Costa Rica Study and a Puerto Rico/Connecticut asthma cohort were used for replication.
resultsIL9, IL5, and proteoglycan 2 expression (PRG2) was upregulated in Der f 1-stimulated PBMCs from dust mite-sensitized patients (adjusted P < .04). IL9 polymorphisms (rs11741137, rs2069885, and rs1859430) showed evidence for interaction with dust mite in the Childhood Asthma Management Program (P = .02 to .03), with replication in the Genetics of Asthma in Costa Rica Study (P = .04). Subjects with the dominant genotype for these IL9 polymorphisms were more likely to report a severe asthma exacerbation if exposed to increased dust mite levels.
conclusionsGenome-wide differential gene expression in response to dust mite allergen identified IL9, a biologically plausible gene target that might interact with environmental dust mite to increase severe asthma exacerbations in children.
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