ArticleViruses2015
A phylogeographic investigation of African monkeypox.
Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID-19 era: A systematic-review.Immunity, inflammation and disease · 2022Pooled it
- Clinical features, hospitalisation and deaths associated with monkeypox: a systematic review and meta-analysis.Annals of clinical microbiology and antimicrobials · 2022Pooled it
- A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy.PLoS neglected tropical diseases · 2019Pooled it
- Serological Survey in African Nonhuman Primate Species in Cameroon and the Democratic Republic of the Congo Reveals Low Overall Seroprevalence to Mpox Virus.The Journal of infectious diseases · 2026Article
- An Emerging Global Threat After The COVID-19 Pandemic: Monkeypox Similarities and Differences.Polish journal of microbiology · 2026Review
- Insights into Genomic Dynamics and Plasticity in the Monkeypox Virus from the 2022 Outbreak.International journal of molecular sciences · 2026Article
- Efficient whole-genome sequencing of Monkeypox virus using a novel nuclease-multiple displacement amplification enrichment method.Npj viruses · 2026Article
- Serological evidence uncovers undocumented mpox exposure in febrile patients in Nigeria.Frontiers in public health · 2026Article
- Decoding the mechanophysiology for inhaled onset of smallpox with model-based implications for mpox spread.Scientific reports · 2025Article
- Squirrel reservoirs of monkeypox virus are sister species separated by the Sanaga River (Cameroon), as are the two main viral clades.One health (Amsterdam, Netherlands) · 2025Article
- Emergence of Clade Ib Monkeypox Virus-Current State of Evidence.Emerging infectious diseases · 2025Review
- Clinical and epidemiological characteristics among probable and confirmed patients with mpox in Sierra Leone reported from January to May 2025.medRxiv : the preprint server for health sciences · 2025Article
- Review
- Mpox virus (MPXV): comprehensive analysis of pandemic risks, pathophysiology, treatments, and mRNA vaccine development.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- A review of epidemiology, diagnosis, and management of Mpox: The role of One Health.Global health & medicine · 2025Review
- Genomic and phenotypic insights into the first imported monkeypox virus clade Ia isolate in China, 2025.Frontiers in public health · 2025Article
- Exploring the Dynamics ofCurrent medicinal chemistry · 2025Article
- Mpox: An emerging or re-emerging infection with a potential colossal burden on healthcare globally.African journal of laboratory medicine · 2025Review
- Screening great ape museum specimens for DNA viruses.Scientific reports · 2024Article
- Evaluation of the mpox surveillance system in Cameroon from 2018 to 2022: a laboratory cross-sectional study.BMC infectious diseases · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monkeypox is a zoonotic disease caused by a virus member of the genus Orthopoxvirus and is endemic to Central and Western African countries. Previous work has identified two geographically disjuct clades of monkeypox virus based on the analysis of a few genomes coupled with epidemiological and clinical analyses; however, environmental and geographic causes of this differentiation have not been explored. Here, we expand previous phylogenetic studies by analyzing a larger set of monkeypox virus genomes originating throughout Sub-Saharan Africa to identify possible biogeographic barriers associated with genetic differentiation; and projected ecological niche models onto environmental conditions at three periods in the past to explore the potential role of climate oscillations in the evolution of the two primary clades. Analyses supported the separation of the Congo Basin and West Africa clades; the Congo Basin clade shows much shorter branches, which likely indicate a more recent diversification of isolates within this clade. The area between the Sanaga and Cross Rivers divides the two clades and the Dahomey Gap seems to have also served as a barrier within the West African clade. Contraction of areas with suitable environments for monkeypox virus during the Last Glacial Maximum, suggests that the Congo Basin clade of monkeypox virus experienced a severe bottleneck and has since expanded its geographic range.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.