Evidence map›Paper›PMID 25912716›Full record

ArticleViruses2015

Genome variability and gene content in chordopoxviruses: dependence on microsatellites.

Eneida L Hatcher, Chunlin Wang, Elliot J Lefkowitz

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eneida L HatcherDepartment of Microbiology, University of Alabama at Birmingham, BBRB 276/11, 845 19th St S, Birmingham, AL 35222, USA. eneidao@uab.edu.
Chunlin WangStanford Genome Technology Center, Stanford University, 855 California Ave, Palo Alto, CA 94304, USA. wangcl@stanford.edu.
Elliot J LefkowitzDepartment of Microbiology, University of Alabama at Birmingham, BBRB 276/11, 845 19th St S, Birmingham, AL 35222, USA. elliotl@uab.edu.
University of Alabama at Birmingham · USStanford University · US

Funding

ORTHOPOXVIRUS GENOMIC AND BIOINFORMATICS RESOURCE CENTERU01AI048706 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEFKOWITZ, ELLIOT J. · 2000 to 2003
$1.6M
NIAID NIH HHS HHSN266200400036CNIAID NIH HHS U01 AI048706NIAID NIH HHS U01 AI48706PHS HHS 266200400036C
6 · The paper itself

Abstract

To investigate gene loss in poxviruses belonging to the Chordopoxvirinae subfamily, we assessed the gene content of representative members of the subfamily, and determined whether individual genes present in each genome were intact, truncated, or fragmented. When nonintact genes were identified, the early stop mutations (ESMs) leading to gene truncation or fragmentation were analyzed. Of all the ESMs present in these poxvirus genomes, over 65% co-localized with microsatellites-simple sequence nucleotide repeats. On average, microsatellites comprise 24% of the nucleotide sequence of these poxvirus genomes. These simple repeats have been shown to exhibit high rates of variation, and represent a target for poxvirus protein variation, gene truncation, and reductive evolution.

Indexed as

Genetic VariationGenome, ViralGenomic InstabilityMicrosatellite RepeatsChordopoxvirinaeCodon, NonsenseComputational BiologyEvolution, MolecularGene DeletionCodon, Nonsense

Identifiers

PMID25912716
PMCPMC4411693
OpenAlexW2125115938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.