ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2015
Shared and distinct neurocognitive endophenotypes of schizophrenia and psychotic bipolar disorder.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders.Molecular psychiatry · 2021Pooled it
- Childhood Trauma and Neurocognition in Adults With Psychotic Disorders: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Infraslow fluctuations of sustained attention in mood disorders.Psychological medicine · 2025Article
- Patterns of Impaired Neurocognitive Performance on the Global Neuropsychological Assessment, and Their Brain Structural Correlates in Recent-onset and Chronic Schizophrenia.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- MICEmi: A method to identify cognitive endophenotypes of mental illnesses.European psychiatry : the journal of the Association of European Psychiatrists · 2022Review
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Familial aggregation analysis of cognitive performance in early-onset bipolar disorder.European child & adolescent psychiatry · 2020Article
- Distinct Associations of Cognitive Impairments and Reduced Gray Matter Volumes in Remitted Patients with Schizophrenia and Bipolar Disorder.Neural plasticity · 2020Article
- Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.Neuropsychology review · 2018Review
- Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2018Article
- Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains.Psychological medicine · 2018Article
- [Neuropsychological Profile and Working Memory in Bipolar Disorder].Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2018Article
- Transdiagnostic impairment of cognitive control in mental illness.Journal of psychiatric research · 2016Review
- The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.Journal of psychiatric research · 2016Article
- Cognitive deficits in first-degree relatives of bipolar patients: the use of homogeneous subgroups in the search of cognitive endophenotypes.Journal of neural transmission (Vienna, Austria : 1996) · 2016Article
- Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSchizophrenia and bipolar disorder are characterized by the presence of neurocognitive impairments on the psychosis continuum. The present study aimed to explore the shared and distinct endophenotypes between these disorders.
methodsThe study included 34 probands with remitted schizophrenia and 34 probands with euthymic bipolar disorder who had a history of psychotic symptoms that met the Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) criteria, unaffected first-degree relatives of probands (31 relatives of probands with schizophrenia and 29 relatives of probands with bipolar disorder), and 34 healthy controls. Cognitive assessments were performed using the digit span, continuous performance, Rey auditory and visual learning, complex figure, verbal fluency, Wisconsin card sorting, and finger tapping tests.
resultsProbands with schizophrenia showed the most generalized and severe cognitive deficits across cognitive domains (working memory, verbal learning and memory, visual memory, verbal fluency, and executive function). Some domains of cognitive function (working memory, verbal learning, and memory) were also impaired in probands with bipolar disorder, but to a lesser degree than in probands with schizophrenia. All probands and relatives showed a common deficit in working memory compared to healthy controls. Relatives of probands with schizophrenia also showed verbal fluency dysfunction. Cognitive performance of all relatives was intermediate to the performance of both patients and healthy controls.
conclusionsThese findings suggest that a deficit in working memory could be a shared endophenotype of genetic vulnerability to schizophrenia and psychotic bipolar disorder, and verbal fluency could be a candidate endophenotype for schizophrenia specifically.
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