ArticleNeurotoxicology2015
Ex vivo magnetic resonance imaging in South African manganese mine workers.
Article in Neurotoxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Prolonged duration induces divergent transcriptomic responses to manganese, distinct from concentration effects, in an SH-SY5Y neurotoxicity model.Neurotoxicology · 2026Article
- Effects of Subchronic Manganese and Iron Exposure, Alone or in Combination, on Elemental Distribution in Rats.Biological trace element research · 2025Article
- Do toenail manganese and iron levels reflect brain metal levels or brain metabolism in welders?Neurotoxicology · 2024Article
- Occupational, environmental, and toxicological health risks of mining metals for lithium-ion batteries: a narrative review of the Pubmed database.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Magnetic Resonance Imaging and Manganism: A Narrative Review and Laboratory Recommendations.Journal of clinical medicine · 2024Review
- Olfactory tract/bulb metal concentration in Manganese-exposed mineworkers.Neurotoxicology · 2024Article
- Welding-related brain and functional changes in welders with chronic and low-level exposure.Neurotoxicology · 2018Article
- Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.Neurotoxicology · 2018Article
- Association of MRI T1 relaxation time with neuropsychological test performance in manganese- exposed welders.Neurotoxicology · 2018Article
- Article
- [Neurotoxicology · 2018Article
- Cognitive control dysfunction in workers exposed to manganese-containing welding fume.American journal of industrial medicine · 2017Article
- Association of neurobehavioral performance with R2* in the caudate nucleus of asymptomatic welders.Neurotoxicology · 2017Article
- "Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies".BMC pharmacology & toxicology · 2016Review
- Editor's Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Marker for Long-Term Welding Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Increased R2* in the Caudate Nucleus of Asymptomatic Welders.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundManganese (Mn) exposure is associated with increased T1-weighted magnetic resonance imaging (MRI) signal in the basal ganglia. T1 signal intensity has been correlated with occupational Mn exposure but not with clinical symptomatology or neuropathology.
objectivesThis study investigated predictors of ex vivo T1 MRI basal ganglia signal intensity in neuropathologic tissue obtained from deceased South African mine workers.
methodsA 3.0 T MRI was performed on ex vivo brain tissue obtained from 19 Mn mine workers and 10 race- and sex-matched mine workers of other commodities. Basal ganglia regions of interest were identified for each subject with T1-weighted intensity indices generated for each region. In a pathology subset, regional T1 indices were compared to neuronal and glial cell density and tissue metal concentrations.
resultsIntensity indices were higher in Mn mine workers than non-Mn mine workers for the globus pallidus, caudate, anterior putamen, and posterior putamen with the highest values in subjects with the longest cumulative Mn exposure. Intensity indices were inversely correlated with the neuronal cell density in the caudate (p=0.040) and putamen (p=0.050). Tissue Mn concentrations were similar in Mn and non-Mn mine workers. Tissue iron (Fe) concentration trended lower across all regions in Mn mine workers.
conclusionsMn mine workers demonstrated elevated basal ganglia T1 indices when compared to non-Mn mine workers. Predictors of ex vivo T1 MRI signal intensity in Mn mine workers include duration of Mn exposure and neuronal density.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.