ArticlePediatric diabetes2015
Arterial stiffness in adolescents and young adults with and without type 1 diabetes: the SEARCH CVD study.
Article in Pediatric diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 79 citations in OpenAlex.
- Sleep duration and association with cardiometabolic health in adolescents and adults with type 1 diabetes: Results from the BCQR-T1D study.Diabetes, obesity & metabolism · 2024Trial
- Bromocriptine quick-release as adjunct therapy in youth and adults with type 1 diabetes: A randomized, placebo-controlled crossover study.Diabetes, obesity & metabolism · 2022Trial
- Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.Journal of diabetes and its complications · 2019Trial
- Effect of Improving Dietary Quality on Arterial Stiffness in Subjects with Type 1 and Type 2 Diabetes: A 12 Months Randomised Controlled Trial.Nutrients · 2016Trial
- Increased 24-h blood pressure and arterial stiffness in young adults with childhood-onset type 1 diabetes: the Norwegian Atherosclerosis and Childhood Diabetes study.Journal of hypertension · 2026Article
- Beyond HbAFrontiers in endocrinology · 2026Review
- Arterial Stiffness and Central Hemodynamics in South Asian, African American, and White Adolescents and Young Adults-The Charisma Study.American journal of hypertension · 2026Article
- Coronary artery calcification in type 1 diabetes after 10-year ketogenic diet.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Young Healthy Individuals With a First-Degree Relative With Type 1 Diabetes Displayed Adverse Lipid Changes.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The Relationship Between Cholesterol Level, Cytokine Profile, and Arterial Stiffness in Young Patients with Uncomplicated Type 1 Diabetes.International journal of molecular sciences · 2025Article
- Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study.Diabetes care · 2025Article
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology · 2024Article
- Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Associations Between Arterial Stiffness and Metabolic Target in Children and Adolescents With Type 1 Diabetes Treated in a Modern Setting.Pediatric diabetes · 2024Article
- Cardioprotective and Antifibrotic Effects of Low-Dose Renin-Angiotensin-Aldosterone System Inhibitors in Type 1 Diabetic Rat Model.International journal of molecular sciences · 2023Article
- Periodontitis and cardiovascular risk factors in subjects with and without type 1 diabetes: A cross sectional analysis.Journal of diabetes and its complications · 2023Article
- Exploring Racial and Ethnic Differences in Arterial Stiffness Among Youth and Young Adults With Type 1 Diabetes.Journal of the American Heart Association · 2023Article
- Is There a Role for Imaging Youth at Risk of Atherosclerosis?Current atherosclerosis reports · 2023Review
- Longitudinal Changes in Arterial Stiffness and Heart Rate Variability in Youth-Onset Type 1 Versus Type 2 Diabetes: The SEARCH for Diabetes in Youth Study.Diabetes care · 2022Article
- Are Clinicians Aggressive Enough in Treating Diabetes-Related Hyperlipidemia in Youth?Current atherosclerosis reports · 2022Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundArterial stiffness is a useful parameter to predict future cardiovascular disease.
objectiveWe sought to compare arterial stiffness in adolescents and young adults with and without type 1 diabetes (T1D) and explore the risk factors associated with the differences observed. SUBJECTS AND
methodsCarotid-femoral pulse wave velocity (PWV), augmentation index (AI75), and brachial distensibility (BrachD) were measured in 402 adolescents and young adults with T1D (age 18.8 ± 3.3 yr, T1D duration 9.8 ± 3.8 yr) and 206 non-diabetic controls that were frequency-matched by age, sex, and race/ethnicity in a cross-sectional study. General linear models were used to explore variables associated with an increase in arterial stiffness after adjustment for demographic and metabolic covariates.
resultsT1D status was associated with a higher PWV (5.9 ± 0.05 vs. 5.7 ± 0.1 m/s), AI75 (1.3 ± 0.6 vs. -1.9 ± 0.7%), and lower BrachD (6.2 ± 0.1 vs. 6.5 ± 0.1%Δ/mmHg), all p < 0.05. In multivariate models, age, sex, race, adiposity, blood pressure, lipids, and the presence of microalbuminuria were found to be independent correlates of increased arterial stiffness. After adjustment for these risk factors, T1D status was still significantly associated with arterial stiffness (p < 0.05).
conclusionsPeripheral and central subclinical vascular changes are present in adolescents and young adults with T1D compared to controls. Increased cardiovascular risk factors alone do not explain the observed differences in arterial stiffness among cases and controls. Identifying other risk factors associated with increased arterial stiffness in youth with T1D is critical to prevent future vascular complications.
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