Evidence map›Paper›PMID 25912144›Full record

ArticleOphthalmology2015

The Most Common Barriers to Glaucoma Medication Adherence: A Cross-Sectional Survey.

Paula Anne Newman-Casey, Alan L Robin, Taylor Blachley, Karen Farris, Michele Heisler, Ken Resnicow, Paul P Lee

5 registry-linked trialsAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 216 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03159247 nacompletednot on this mapstarted 2017, after this paper: background citation

The eyeGuide: Improving Glaucoma Self-management With a Personalized Behavior Change Program

TypeinterventionalSponsorUniversity of MichiganRan2017 to 2020Enrolled107ConditionsMedication Adherence, GlaucomaArmseyeGuide
NCT04200651 phase4terminatednot on this mapstarted 2020, after this paper: background citation

Prospective Study on DEXTENZA® Safety And Efficacy Following Concomitant MIGS and Cataract Surgery

TypeinterventionalSponsorThe New York Eye Surgery CenterRan2020 to 2023Enrolled25ConditionsGlaucoma, CataractArmsDexamethasone Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
NCT06045390 nacompletednot on this mapstarted 2024, after this paper: background citation

Assessing the Effects of an In-office, Language-concordant App on Eye Drop Recall in Patients With Multi-drop Regimens

TypeinterventionalSponsorUniversity of California, San FranciscoRan2024 to 2025Enrolled20ConditionsGlaucomaArmsApp
NCT06761313 phase4active not recruitingnot on this mapstarted 2021, after this paper: background citation

Triplenex (triple Fixed Combination) Use Evaluation in Patients with Glaucoma: Randomized Clinical Trial

TypeinterventionalSponsorFederal University of São PauloRan2021 to 2025Enrolled40ConditionsGlaucoma, Quality of Life (QOL)ArmsTriple combination formula, Bimatoprost .03% sterile ophthalmic solution
NCT07793474 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Eye Patient Adherence and Compliance Study-Intervention Program (EYE-PACIP): Improving Glaucoma Adherence and Compliance in High-risk Patients With a Multi-interventional Program

TypeinterventionalSponsorSt. Joseph's Healthcare HamiltonRan2026 to 2028Enrolled189ConditionsGlaucoma Medication Adherence, Glaucoma PatientsArmsEye Droppers, Eye Educate, Eye Coordinate, Eye Help, Eye Refer
3 · Its place in the literature

Who cites it

216 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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156 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Paula Anne Newman-CaseyDepartment of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address: panewman@med.umich.edu.
Alan L RobinDepartment of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan; Department of Ophthalmology & International Health, Johns Hopkins University, Baltimore, Maryland.
Taylor BlachleyDepartment of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan.
Karen FarrisSchool of Pharmacy, University of Michigan, Ann Arbor, Michigan.
Michele HeislerSchool of Public Health, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Ken ResnicowSchool of Public Health, University of Michigan, Ann Arbor, Michigan.
Paul P LeeDepartment of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan.

Funding

Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
NEI NIH HHS K12 EY022299NEI NIH HHS K12EY022299
6 · The paper itself

Abstract

purposeTo evaluate the frequency of 11 commonly cited barriers to optimal glaucoma medication adherence among glaucoma patients and to identify barriers contributing to poor adherence.

designProspective, cross-sectional survey.

participantsOne hundred ninety adults with glaucoma taking 1 or more glaucoma medication who received care in glaucoma clinics in Ann Arbor, Michigan, and Baltimore, Maryland.

methodsParticipants completed a survey on demographic and disease characteristics, barriers to optimal glaucoma medication adherence, interest in an eye drop aid, and self-reported adherence (measured by the Morisky Adherence Scale). Descriptive statistics and logistic regression analyses were performed.

main outcome measuresFrequency and number of barriers to adherence among both adherent and nonadherent patients. Odds ratios (ORs) with 95% confidence intervals (CIs) identifying barriers associated with poor adherence.

resultsTwenty-seven percent of the sample reported poor adherence. Sixty-one percent of all participants cited multiple barriers and 10% cited a single barrier as impediments to optimal adherence. Twenty-nine percent of subjects cited no barriers, although only 13% of patients who cited no barriers were nonadherent. Among nonadherent patients, 31% or more cited each of the 11 barriers as important. Logistic regression analysis, adjusted for age, revealed that the following barriers were associated with higher odds of nonadherence: decreased self-efficacy (OR, 4.7; 95% CI, 2.2-9.7; P ≤ 0.0001), difficulty instilling drops (OR, 2.3; 95% CI, 1.1-4.9; P = 0.03), forgetfulness (OR, 5.6; 95% CI, 2.6-12.1; P ≤ 0.0001), and difficulties with the medication schedule (OR, 2.9; 95% CI, 1.4-6.0; P = 0.006). For each additional barrier cited as important, there was a 10% increased odds of being nonadherent (OR, 1.1; 95% CI, 1.0-1.2; P = 0.01).

conclusionsEach of the 11 barriers was important to at least 30% of surveyed patients with poor adherence, with most identifying multiple barriers to adherence. Low self-efficacy, forgetfulness, and difficulty with drop administration and the medication schedule were barriers associated with poor adherence. Interventions to improve medication adherence must address each patient's unique set of barriers.

Indexed as

Drug MonitoringAgedAntihypertensive AgentsCross-Sectional StudiesEducational StatusFemaleGlaucoma, Open-AngleHealth Services AccessibilityHealth StatusHealth SurveysHumansIntraocular PressureMaleMarylandMichiganMiddle AgedAntihypertensive AgentsOphthalmic Solutions

Identifiers

PMID25912144
PMCPMC4485580

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.