ArticleJournal of experimental botany2015
Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed.
- Regulatory Roles of PURPLE FRUIT 1 and OsPa in Pigmentation of Rice Grain.Rice (New York, N.Y.) · 2026Article
- Molecular mechanism of ethylene signaling response gene VcERF061 to promote anthocyanin synthesis in blueberry (Vaccinium corymbosum).BMC plant biology · 2025Article
- Fine-Mapping of a Red-Skinned Taproot Gene in Radish (Plants (Basel, Switzerland) · 2025Article
- Beyond IbMYB1: Identification and Characterization of Two Additional Anthocyanin MYB Activators, IbMYB2 and IbMYB3, in Sweetpotato.Plants (Basel, Switzerland) · 2025Article
- Generation and characterization of rice OsCENH3 mutants for haploid induction.Plant cell reports · 2025Article
- Two B-Box Proteins, GhBBX21 and GhBBX24, Antagonistically Modulate Anthocyanin Biosynthesis inPlants (Basel, Switzerland) · 2025Article
- The road less taken: Dihydroflavonol 4-reductase inactivation and delphinidin anthocyanin loss underpins a natural intraspecific flower colour variation.Molecular ecology · 2025Article
- Integrated omics and functional insights into BjMYB90-mediated regulation of BjGSTF12 for enhanced anthocyanin biosynthesis in mustard (Brassica juncea).Plant cell reports · 2025Article
- Molecular mechanisms driving the unusual pigmentation shift during eggplant fruit development.Plant communications · 2025Article
- Anthocyanins and Anthocyanin Biosynthesis Gene Expression inPlants (Basel, Switzerland) · 2025Article
- CaMYBA-CaMYC-CaTTG1 complex activates the transcription of anthocyanin synthesis structural genes and regulates anthocyanin accumulation in pepper (Frontiers in plant science · 2025Article
- Article
- A Regulatory Mechanism on Pathways: Modulating Roles of MYC2 and BBX21 in the Flavonoid Network.Plants (Basel, Switzerland) · 2024Article
- Overexpression ofFrontiers in plant science · 2024Article
- Metabolic GWAS-based dissection of genetic basis underlying nutrient quality variation and domestication of cassava storage root.Genome biology · 2023Article
- Genome-Wide Identification of PAP1 Direct Targets in Regulating Seed Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2023Article
- Article
- The MYB transcription factor RcMYB1 plays a central role in rose anthocyanin biosynthesis.Horticulture research · 2023Article
- Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2023Article
- Effect of structural variation in the promoter region ofFrontiers in plant science · 2023Article
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9 authors.
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Abstract
Cellular activities such as compound synthesis often require the transcriptional activation of an entire pathway; however, the molecular mechanisms underlying pathway activation have rarely been explained. Here, the cis regulatory architecture of the anthocyanin pathway genes targeted by the transcription factor (TF) complex including MYB, bHLH, and WDR was systematically analysed in one species and the findings extended to others. In Ipomoea purpurea, the IpMYB1-IpbHLH2-IpWDR1 (IpMBW) complex was found to be orthologous to the PAP1-GL3-TTG1 (AtPGT) complex of Arabidopsis thaliana, and interacted with a 7-bp MYB-recognizing element (MRE) and a 6-bp bHLH-recognizing element (BRE) at the proximal promoter region of the pathway genes. There was little transcription of the gene in the absence of the MRE or BRE. The cis elements identified experimentally converged on two syntaxes, ANCNNCC for MREs and CACN(A/C/T)(G/T) for BREs, and our bioinformatic analysis showed that these were present within anthocyanin gene promoters in at least 35 species, including both gymnosperms and angiosperms. For the anthocyanin pathway, IpMBW and AtPGT recognized the interspecific promoters of both early and later genes. In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. When multiple TF complexes in the anthocyanin pathway were compared, the cis architecture played a role larger than the TF complex in determining the variation in promoter activity. Collectively, a cis logic common to the pathway gene promoters was found, and this logic is essential for the trans factors to regulate the pathway.
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