Evidence map›Paper›PMID 25911681›Full record

ReviewJournal of applied physiology (Bethesda, Md. : 1985)2015

Determinants of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction.

Mark J Haykowsky, Corey R Tomczak, Jessica M Scott, D Ian Paterson, Dalane W Kitzman

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04241159 (A Small-Scale Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults Experiencing Disability Across the Spectrum of Frailty Syndrome), which is not on this map. Cited by 108 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 9 pooled it
45.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04241159 early_phase1withdrawnnot on this mapstarted 2020, after this paper: background citation

A Small-Scale Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults Experiencing Disability Across the Spectrum of Frailty Syndrome

TypeinterventionalSponsorWake Forest University Health SciencesRan2020 to 2020Enrolled0ConditionsFrailty Syndrome, Heart FailureArmsAllogeneic Young Plasma
3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 9 syntheses or guidelines pooled it, 187 citations in OpenAlex.

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  12. Effect of closed loop stimulation versus accelerometer on outcomes with cardiac resynchronization therapy: the CLASS trial.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
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  14. Dietary Nitrate Increases VOJournal of cardiac failure · 2018
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Mark J HaykowskyFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada; mhaykows@gmail.com.
Corey R TomczakCollege of Kinesiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;
Jessica M ScottUniversities Space Research Association, Houston, Texas; and.
D Ian PatersonFaculty of Medicine (Division of Cardiology), University of Alberta, Edmonton, Alberta, Canada;
Dalane W KitzmanDepartment of Internal Medicine, Sections on Cardiology and Geriatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina.
University of Alberta · CAUniversities Space Research Association · USUniversity of Saskatchewan · CAWake Forest University · US

Funding

REHAB-HF: A Trial of Rehabilitation Therapy in Older Acute Heart Failure PatientsR01AG045551 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2014 to 2018
$6.8M
SPRINT - HeartR01HL107257 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL107257NIA NIH HHS R01 AG045551NIA NIH HHS R0AG118915
6 · The paper itself

Abstract

This mini-review summarizes the literature regarding the mechanisms of exercise intolerance in patients with heart failure and reduced or preserved ejection fraction (HFREF and HFPEF, respectively). Evidence to date suggests that the reduced peak pulmonary oxygen uptake (pulm V̇o₂) in patients with HFREF compared with healthy controls is due to both central (reduced convective O₂ transport) and peripheral factors (impaired skeletal muscle blood flow, decreased diffusive O₂ transport coupled with abnormal skeletal morphology, and metabolism). Although central and peripheral impairments also limit peak pulm V̇o₂ in HFPEF patients compared with healthy controls, emerging data suggest that the latter may play a relatively greater role in limiting exercise performance in these patients. Unlike HFREF, currently there is limited evidence-based therapies that improve exercise capacity in HFPEF patients, therefore future studies are required to determine whether interventions targeted to improve peripheral vascular and skeletal muscle function result in favorable improvements in peak pulm and leg V̇o2 and their determinants in HFPEF patients.

Indexed as

ExerciseExercise ToleranceHeart FailureHumansMuscle, SkeletalOxygen Consumptionexercise physiologyheart failure and preserved ejection fractionheart failure and reduced ejection fraction

Identifiers

PMID25911681
PMCPMC4687865
OpenAlexW2331955915

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.