Evidence map›Paper›PMID 25911572›Full record

ArticleBMJ (Clinical research ed.)2015

Development of phenotype algorithms using electronic medical records and incorporating natural language processing.

Katherine P Liao, Tianxi Cai, Guergana K Savova, Shawn N Murphy, Elizabeth W Karlson, Ashwin N Ananthakrishnan, Vivian S Gainer, Stanley Y Shaw, Zongqi Xia, Peter Szolovits and 2 more

2 registry-linked trialsAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 166 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
NCT04757233 nacompletednot on this mapstarted 2018, after this paper: background citation

Dynamically Tailoring Interventions for Problem-Solving in Diabetes Self-Management Using Self-Monitoring Data

TypeinterventionalSponsorColumbia UniversityRan2018 to 2018Enrolled20ConditionsType 2 Diabetes MellitusArmsGlucoType
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Physicians' perspectives on clinical indicators: systematic review and thematic synthesis.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2024
    Pooled it
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  8. Natural Language Processing Algorithm Accurately Classifies Diverticulitis-Related Complications and Predicts Long-Term Outcomes.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Article
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  14. Review
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Katherine P LiaoDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Harvard Medical School, Boston kliao@partners.org.
Tianxi CaiDepartment of Biostatistics, Harvard School of Public Health, Boston.
Guergana K SavovaDepartment of Pediatrics, Children's Hospital of Boston, Boston.
Shawn N MurphyDepartment of Neurology, Massachusetts General Hospital, Boston.
Elizabeth W KarlsonDivision of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA Harvard Medical School, Boston.
Ashwin N AnanthakrishnanDepartment of Gastroenterology, Massachusetts General Hospital, MGH Crohn's and Colitis Center, Boston.
Vivian S GainerPartners Research Computing, Partners HealthCare System, Boston.
Stanley Y ShawHarvard Medical School, Boston Center for Systems Biology, Massachusetts General Hospital, Boston.
Zongqi XiaHarvard Medical School, Boston Department of Neurology, Harvard Medical School, Boston.
Peter SzolovitsDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA.
Susanne ChurchillHarvard Medical School, Boston.
Isaac KohaneHarvard Medical School, Boston Department of Neurology, Massachusetts General Hospital, Boston.

Funding

Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Leveraging genetics and environment to predict presymptomatic multiple sclerosisK08NS079493 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XIA, ZONGQI · 2012 to 2016
$957k
Genetic predictors of anti-TNF treatment response and infections in IBDK23DK097142 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ANANTHAKRISHNAN, ASHWIN N · 2012 to 2016
$846k
Genetic Risk Factors for Coronary Artery Disease in Rheumatoid ArthritisK08AR060257 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LIAO, KATHERINE PHOENIX · 2011 to 2015
$649k
NIAMS NIH HHS AR 060257NIAMS NIH HHS K08 AR060257NIDDK NIH HHS K08 K23 DK097142NIDDK NIH HHS P30 DK043351NINDS NIH HHS K08 NS079493NLM NIH HHS U54 LM008748NLM NIH HHS U54LM008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlgorithmsElectronic Health RecordsNatural Language ProcessingPhenotypeHumansInformation Storage and RetrievalInterdisciplinary CommunicationTranslational Research, Biomedical

Identifiers

PMID25911572
PMCPMC4707569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.