ArticleMedical hypotheses2015
A central theory of biology.
Article in Medical hypotheses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 62 citations in OpenAlex.
- Reappraising the exteriorization of the mammalian testes through evolutionary physiology.Communicative & integrative biology · 2019Review
- The evolution of "Life": A Metadarwinian integrative approach.Communicative & integrative biology · 2017Article
- The Molecular Apgar Score: A Key to Unlocking Evolutionary Principles.Frontiers in pediatrics · 2017Article
- Phenotype as Agent for Epigenetic Inheritance.Biology · 2016Article
- Article
- Cognition, Information Fields and Hologenomic Entanglement: Evolution in Light and Shadow.Biology · 2016Article
- The Cell as the First Niche Construction.Biology · 2016Article
- Life Is Simple-Biologic Complexity Is an Epiphenomenon.Biology · 2016Article
- Article
- Article
- On the Evolution of the Mammalian Brain.Frontiers in systems neuroscience · 2016Article
- The Eukaryotic Microbiome: Origins and Implications for Fetal and Neonatal Life.Frontiers in pediatrics · 2016Review
- Homeostasis as the Mechanism of Evolution.Biology · 2015Article
- Article
- Life and evolution as physics.Communicative & integrative biologyArticle
- What We Talk About When We Talk About Evolution.Cell communication insightsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The history of physiologic cellular-molecular interrelationships can be traced all the way back to the unicellular state by following the pathway formed by lipids ubiquitously accommodating calcium homeostasis, and its consequent adaptive effects on oxygen uptake by cells, tissues and organs. As a result, a cohesive, mechanistically integrated view of physiology can be formulated by recognizing the continuum comprising conception, development, physiologic homeostasis and death mediated by soluble growth factor signaling. Seeing such seemingly disparate processes as embryogenesis, chronic disease and dying as the gain and subsequent loss of cell-cell signaling provides a novel perspective for physiology and medicine. It is emblematic of the self-organizing, self-referential nature of life, starting from its origins. Such organizing principles obviate the pitfalls of teleologic evolution, conversely providing a way of resolving such seeming dichotomies as holism and reductionism, genotype and phenotype, emergence and contingence, proximate and ultimate causation in evolution, cells and organisms. The proposed approach is scale-free and predictive, offering a Central Theory of Biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.