ReviewCurrent genetics2015
Insights into the cellular responses to hypoxia in filamentous fungi.
Review in Current genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Analysis of Short-Term Responses to Hypoxia During Stirred-Tank Fermentation inJournal of fungi (Basel, Switzerland) · 2026Article
- Low Oxygen Availability Increases Itaconate Production by Ustilago maydis.Biotechnology and bioengineering · 2025Article
- Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan.EMBO reports · 2025Article
- High Carbon Dioxide Concentration Inhibits Pileus Growth ofJournal of fungi (Basel, Switzerland) · 2025Article
- Strain selection and adaptation of a fungal-yeast-microalgae consortium for sustainable bioethanol production and wastewater treatment from livestock wastewater.Microbial cell factories · 2024Article
- Exploiting the roles of nitrogen sources for HEA increment inFrontiers in microbiology · 2024Article
- Hypoxia Effects onPathogens (Basel, Switzerland) · 2022Article
- Impact of Fungal Hyphae on Growth and Dispersal of Obligate Anaerobic Bacteria in Aerated Habitats.mBio · 2022Article
- Fungal Diversity in Two Wastewater Treatment Plants in North Italy.Microorganisms · 2022Article
- Novel Insights intoJournal of fungi (Basel, Switzerland) · 2022Review
- Exploration and characterization of hypoxia-inducible endogenous promoters in Aspergillus niger.Applied microbiology and biotechnology · 2021Article
- Improving Hypoxia Adaption Causes Distinct Effects on Growth and Bioactive Compounds Synthesis in an Entomopathogenic FungusFrontiers in microbiology · 2021Article
- Hypoxia: A Double-Edged Sword During Fungal Pathogenesis?Frontiers in microbiology · 2020Review
- Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris.MicrobiologyOpen · 2019Article
- Transcriptomic analysis reveals candidate genes regulating development and host interactions of Colletotrichum fructicola.BMC genomics · 2018Article
- Role of actin depolymerizing factor cofilin in Aspergillus fumigatus oxidative stress response and pathogenesis.Current genetics · 2018Article
- FreB is involved in the ferric metabolism and multiple pathogenicity-related traits of Verticillium dahliae.Current genetics · 2018Article
- Interactome analysis of transcriptional coactivator multiprotein bridging factor 1 unveils a yeast AP-1-like transcription factor involved in oxidation tolerance of mycopathogen Beauveria bassiana.Current genetics · 2018Article
- Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species.Microbial biotechnology · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most eukaryotes require molecular oxygen for growth. In general, oxygen is the terminal electron acceptor of the respiratory chain and represents an important substrate for the biosynthesis of cellular compounds. However, in their natural environment, such as soil, and also during the infection, filamentous fungi are confronted with low levels of atmospheric oxygen. Transcriptome and proteome studies on the hypoxic response of filamentous fungi revealed significant alteration of the gene expression and protein synthesis upon hypoxia. These analyses discovered not only common but also species-specific responses to hypoxia with regard to NAD(+) regeneration systems and other metabolic pathways. A surprising outcome was that the induction of oxidative and nitrosative stress defenses during oxygen limitation represents a general trait of adaptation to hypoxia in many fungi. The interplay of these different stress responses is poorly understood, but recent studies have shown that adaptation to hypoxia contributes to virulence of pathogenic fungi. In this review, results on metabolic changes of filamentous fungi during adaptation to hypoxia are summarized and discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.