ArticleJournal of oral microbiology2015
Phenotype, genotype, and antibiotic susceptibility of Swedish and Thai oral isolates of Staphylococcus aureus.
Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- The Oral Cavity-Another Reservoir of Antimicrobial-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- The Eradication ofPathogens (Basel, Switzerland) · 2023Article
- In Vitro Assessment of Biofilm Production, Antibacterial Resistance ofMicroorganisms · 2023Article
- Genetic Characterization ofPathogens (Basel, Switzerland) · 2022Article
- Antimicrobial Resistance and Molecular Epidemiological Characteristics of Methicillin-Resistant and Susceptible Staphylococcal Isolates from Oral Cavity of Dental Patients and Staff in Northern Japan.Antibiotics (Basel, Switzerland) · 2021Article
- Presence of non-oral bacteria in the oral cavity.Archives of microbiology · 2021Review
- Low prevalence of multi-resistant bacteria in undergraduate dental students; an observational case-control multi-centre study in Europe.Journal of oral microbiology · 2021Article
- Distribution and antibiotic-resistance of differentJournal of oral microbiology · 2021Article
- Presence of egc-positive major clones ST 45, 30 and 22 among methicillin-resistant and methicillin-susceptible oral Staphylococcus aureus strains.Scientific reports · 2020Article
- Detection ofSaudi journal of biological sciences · 2020Article
- The Protective Role of Front-Closed and Front-Open Gowns Against Staphylococcus Aureus Contamination of Dental Students before and after Restorative Treatments.Journal of dentistry (Shiraz, Iran) · 2018Article
- Knowledge, attitudes and practices regarding methicillin-resistant Staphylococcus aureus (MRSA) infection control and nasal MRSA carriage rate among dental health-care professionals.International dental journal · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study investigated phenotypes, virulence genotypes, and antibiotic susceptibility of oral Staphylococcus aureus strains in order to get more information on whether oral infections with this bacterium are associated with certain subtypes or related to an over-growth of the S. aureus variants normally found in the oral cavity of healthy carriers. MATERIALS AND
methodsA total number of 157 S. aureus strains were investigated. Sixty-two strains were isolated from Swedish adults with oral infections, 25 strains were from saliva of healthy Swedish dental students, and 45 strains were from tongue scrapings of HIV-positive subjects in Thailand, and 25 Thai strains from non-HIV controls. The isolates were tested for coagulase, nitrate, arginine, and hemolysin, and for the presence of the virulence genes: hlg, clfA, can, sdrC, sdrD, sdrE, map/eap (adhesins) and sea, seb, sec, tst, eta, etb, pvl (toxins). MIC90 and MIC50 were determined by E-test against penicillin V, oxacillin, amoxicillin, clindamycin, vancomycin, fusidic acid, and cefoxitin.
resultsWhile the hemolytic phenotype was significantly (p<0.001) more common among the Thai strains compared to Swedish strains, the virulence genes were found in a similar frequency in the S. aureus strains isolated from all four subject groups. The Panton-Valentine leukocidin (PVL) genotype was found in 73-100% of the strains. More than 10% of the strains from Swedish oral infections and from Thai HIV-positives showed low antibiotic susceptibility, most commonly for clindamycin. Only three methicillin-resistant S. aureus (MRSA) strains were identified, two from oral infections and one from a Thai HIV patient.
conclusionsS. aureus is occasionally occurring in the oral cavity in both health and disease in Sweden and Thailand. It is therefore most likely that S. aureus in opportunistic oral infections originate from the oral microbiota. S. aureus should be considered in case of oral infections and complaints and the antibiotic susceptibility (including MRSA) should regularly be checked. The frequent presence of S. aureus, although in low numbers among students and staff, emphasizes the importance of standard infection control precautions and of using diagnostic test in the dental clinic.
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