ArticleThe Journal of biological chemistry2015
Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease.Nature reviews. Molecular cell biology · 2026Review
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Bridging the gap: an emerging link between tubulinopathies and ciliopathies.NPJ genomic medicine · 2026Review
- Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression changes in the hippocampus.Nature communications · 2025Article
- Article
- Brief Electrical Stimulation Promotes Recovery after Surgical Repair of Injured Peripheral Nerves.International journal of molecular sciences · 2024Review
- Role of tubulin post-translational modifications in peripheral neuropathy.Experimental neurology · 2023Review
- Microfluidic Manipulation for Biomedical Applications in the Central and Peripheral Nervous Systems.Pharmaceutics · 2023Review
- Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design.PLoS computational biology · 2022Article
- Review
- The role of α-tubulin tyrosination in controlling the structure and function of hippocampal neurons.Frontiers in molecular neuroscience · 2022Article
- Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth.Scientific reports · 2021Article
- Protein post-translational modifications after spinal cord injury.Neural regeneration research · 2021Review
- Tubulin post-translational modifications control neuronal development and functions.Developmental neurobiology · 2021Review
- In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic Nerves.Molecular neurobiology · 2021Article
- Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Ascending dorsal column sensory neurons respond to spinal cord injury and downregulate genes related to lipid metabolism.Scientific reports · 2021Article
- Effect of TTLL12 on tubulin tyrosine nitration as a novel target for screening anticancer drugsOncology letters · 2020Article
- Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury.Nature communications · 2020Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Injured peripheral neurons successfully activate a pro-regenerative program to enable axon regeneration and functional recovery. The microtubule-dependent retrograde transport of injury signals from the lesion site in the axon back to the cell soma stimulates the increased growth capacity of injured neurons. However, the mechanisms initiating this retrograde transport remain poorly understood. Here we show that tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated α-tubulin at the axon injury site and plays an important role in injury signaling. Preventing the injury-induced increase in tyrosinated α-tubulin by knocking down TTL impairs retrograde organelle transport and delays activation of the pro-regenerative transcription factor c-Jun. In the absence of TTL, axon regeneration is reduced severely. We propose a model in which TTL increases the levels of tyrosinated α-tubulin locally at the injury site to facilitate the retrograde transport of injury signals that are required to activate a pro-regenerative program.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.