ArticleNetherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation2015
Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease.
Article in Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06172790 (Investigation of the Effects of the Otago Exercise Program in Adults With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effects of the Otago Exercise Program in Adults With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Palliative care in pulmonary hypertension associated with congenital heart disease: systematic review and expert opinion.ESC heart failure · 2021Pooled it
- Systematic Review of Health-Related Quality of Life in Patients with Pulmonary Arterial Hypertension.PharmacoEconomics · 2016Pooled it
- Health-related quality of life among adults with chronic diseases: a linked, retrospective cohort study using the EQ-5D-5L in Queensland, Australia.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Meldonium Improves Functional Capacity in Patients with Right Ventricular Failure.Journal of clinical medicine · 2025Article
- Age moderates change in disease-related stress among congenital heart disease survivors: a 6-year follow-up.European journal of cardiovascular nursing · 2024Article
- Health-Related Quality of Life and Its Association With Outcomes in Adults With Congenital Heart Disease and Heart Failure: Insight From FRESH-ACHD Registry.Journal of the American Heart Association · 2023Article
- Relationship between Multimorbidity and Quality of Life in a Primary Care Setting: The Mediating Role of Dyspnea.Journal of clinical medicine · 2022Article
- Exercise as a multi-modal disease-modifying medicine in systemic sclerosis: An introduction by The Global Fellowship on Rehabilitation and Exercise in Systemic Sclerosis (G-FoRSS).Best practice & research. Clinical rheumatology · 2021Review
- Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes.Diagnostics (Basel, Switzerland) · 2021Review
- Using path analysis to investigate the relationships between depression, anxiety, and health-related quality of life among patients with coronary artery disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Symptom severity and its effect on health-related quality of life over time in patients with pulmonary hypertension: a multisite longitudinal cohort study.BMJ open respiratory research · 2018Article
- Attachment Style Is Related to Quality of Life for Assistance Dog Owners.International journal of environmental research and public health · 2017Article
- A survey of the impact of owning a service dog on quality of life for individuals with physical and hearing disability: a pilot study.Health and quality of life outcomes · 2017Article
- Treatment of pulmonary arterial hypertension in congenital heart disease in Singapore versus the Netherlands: age exceeds ethnicity in influencing clinical outcome.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Adaptation and validation of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for the Netherlands.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Echocardiographic findings associated with mortality ortransplant in patients with pulmonary arterial hypertension:A systematic review and meta-analysis.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Review
- Pulmonary hypertension: the importance of a multidisciplinary approach.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Dyspnea, depression and health related quality of life in pulmonary arterial hypertension patients.Journal of exercise rehabilitation · 2015Article
- Quality of life in pulmonary arterial hypertension.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDecrease in quality of life (QoL) in left-sided heart failure precedes poor survival, which can be reversed with exercise training. We investigated whether QoL is associated with mortality in pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) patients.
methodsIn this observational study, PAH-CHD adults referred for PAH-specific therapy were included. QoL surveys (SF36) were recorded during 2 years of therapy. Based on shift in SF36 scores during this period, patients had either decreased or non-decreased QoL. Subsequently, the patients were followed for mortality.
resultsThirty-nine PAH-CHD patients (mean age 42, 44 % male, 49 % Down's syndrome) were analysed. Following PAH-specific therapy, SF36 physical component summary (PCS) decreased in 13 (35-31 points, p = 0.001) and showed no decrease in 26 patients (34-43 points, mean values, p < 0.001). Post-initiation phase, median follow-up was 4.5 years, during which 12 deaths occurred (31 %), 10 (56 %) in the decreased and 2 (10 %) in the non-decreased group (p = 0.002). Cox regression showed a decrease in SF36 PCS predicted mortality (HR 3.4, 95 % CI 1.03-11, p = 0.045).
conclusionsIn PAH-CHD patients, decrease in SF36 PCS following initiation of PAH-specific therapy is a determinant of mortality.
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