Evidence map›Paper›PMID 25910846›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015

Dietary Fatty Acids and Temperature Modulate Mitochondrial Function and Longevity in Drosophila.

Marissa A Holmbeck, David M Rand

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Thermochemolysis-gas chromatographic detection of oxidized fatty acids in a single Drosophila melanogaster individual.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Article
  2. Review
  3. Antioxidant Activity of Hemp (Antioxidants (Basel, Switzerland) · 2021
    Article
  4. Article
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  11. The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  12. Article
  13. AyurvedicJournal of biosciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marissa A HolmbeckDepartment of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island. David_Rand@Brown.edu.
David M RandDepartment of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island.
Brown University · US

Funding

Nuclear-Mitochondrial Fitness Interactions in DrosophilaR01GM067862 · NIGMS · BROWN UNIVERSITY · PI RAND, DAVID M · 2004 to 2020
$5.1M
Mitochondrial Genetics of Aging in DrosophilaR01AG027849 · NIA · BROWN UNIVERSITY · PI RAND, DAVID M · 2009 to 2013
$1.5M
A Mitochondrial Hub for Dietary Restriction and AgingF31AG040925 · NIA · BROWN UNIVERSITY · PI HOLMBECK, MARISSA · 2011 to 2013
$79k
NIA NIH HHS 1F31AG040925-02NIA NIH HHS F31 AG040925NIA NIH HHS R01AG027849NIGMS NIH HHS R01 GM067862NIGMS NIH HHS R01GM067862
6 · The paper itself

Abstract

Fluctuations in temperature and resource availability are conditions many organisms contend with in nature. Specific dietary nutrients such as fatty acids play an essential role in reproduction, cold adaptation, and metabolism in a variety of organisms. The present study characterizes how temperature and diet interact to modulate Drosophila physiology and life span. Flies were raised on media containing specific saturated, monounsaturated, or polyunsaturated fatty acids supplements at low concentrations and were placed in varied thermal environments. We found that dietary long-chain polyunsaturated fatty acids improve chill coma recovery and modulate mitochondrial function. Additionally, monounsaturated and polyunsaturated fatty acid food supplements were detrimental to life span regardless of temperature, and antioxidants were able to partially rescue this effect. This study provides insight into environmental modulation of Drosophila physiology and life span.

Indexed as

DietDietary FatsFatty AcidsTemperatureAnimalsDrosophilaLarvaLongevityMitochondriaDietary FatsFatty AcidsAntioxidantDietDrosophilaFatty acidsLongevity.Temperature

Identifiers

PMID25910846
PMCPMC4612386
OpenAlexW2013789122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.