Evidence map›Paper›PMID 25910700›Full record

ArticleBioinformatics (Oxford, England)2015

iFoldRNA v2: folding RNA with constraints.

Andrey Krokhotin, Kevin Houlihan, Nikolay V Dokholyan

Open access · bronzeAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 134 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
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  8. Article
  9. Has AlphaFold3 achieved success for RNA?Acta crystallographica. Section D, Structural biology · 2025
    Article
  10. Article
  11. Review
  12. Transformers in RNA structure prediction: A review.Computational and structural biotechnology journal · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrey KrokhotinDepartment of Biochemistry & Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kevin HoulihanDepartment of Biochemistry & Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
Nikolay V DokholyanDepartment of Biochemistry & Biophysics, University of North Carolina, Chapel Hill, NC, 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

Retroviral Genomic RNA Dimer Structure and FunctionR01GM064803 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEEKS, KEVIN M · 2002 to 2016
$3.7M
NIGMS NIH HHS GM064803
6 · The paper itself

Abstract

unlabelledA key to understanding RNA function is to uncover its complex 3D structure. Experimental methods used for determining RNA 3D structures are technologically challenging and laborious, which makes the development of computational prediction methods of substantial interest. Previously, we developed the iFoldRNA server that allows accurate prediction of short (<50 nt) tertiary RNA structures starting from primary sequences. Here, we present a new version of the iFoldRNA server that permits the prediction of tertiary structure of RNAs as long as a few hundred nucleotides. This substantial increase in the server capacity is achieved by utilization of experimental information such as base-pairing and hydroxyl-radical probing. We demonstrate a significant benefit provided by integration of experimental data and computational methods. AVAILABILITY AND IMPLEMENTATION: http://ifoldrna.dokhlab.org CONTACT: dokh@unc.eu.

Indexed as

AlgorithmsBase PairingSoftwareComputational BiologyComputer SimulationHydroxyl RadicalModels, MolecularNucleic Acid ConformationRNASequence Analysis, RNAHydroxyl RadicalRNA

Identifiers

PMID25910700
PMCPMC4547609
OpenAlexW2136295476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.