Evidence map›Paper›PMID 25910642›Full record

ArticleCellular immunology2015

CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells.

Chunfang Zhao, Idania Marrero, Aditi Narsale, Rosita Moya, Joanna D Davies

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. CD73 Expression by CD4Immunology · 2025
    Article
  2. Article
  3. Human CD4Clinical immunology (Orlando, Fla.) · 2018
    Article
  4. Loss of GαScientific reports · 2017
    Article
  5. Normal Thymocyte Egress, T Cell Trafficking, and CD4Journal of immunology (Baltimore, Md. : 1950) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chunfang ZhaoTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A. Electronic address: azhao@biolegend.com.
Idania MarreroTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A. Electronic address: imarrero@tpims.org.
Aditi NarsaleTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A.
Rosita MoyaTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A.
Joanna D DaviesTorrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, U.S.A. Electronic address: jdavies@sdbri.org.
General Atomics (United States) · US

Funding

(PQD6)The Role of Immune Homeostasis in Protection from Cancer CachexiaR01CA185349 · NCI · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI DAVIES, JOANNA D · 2014 to 2017
$1.2M
CD4+ T cells in the control of cachexiaR01CA109729 · NCI · TORREY PINES INST FOR MOLECULAR STUDIES · PI DAVIES, JOANNA D · 2006 to 2008
$760k
NCI NIH HHS CA109729NCI NIH HHS R01 CA109729NCI NIH HHS R01 CA185349
6 · The paper itself

Abstract

CD4(+) CD44(v.low) cells are peripheral precursor T cells that inhibit lymphopenia by generating a large CD4(+) T cell pool containing balanced numbers of naïve, memory, and regulatory Foxp3(+) cells with a diverse TCR repertoire. Recent thymic emigrants (RTE) and stem cell-like memory T cells (T(SCM)) can also replenish a T cell pool. In this study we formally test whether CD44(v.low) cells are the same population as RTE and T(SCM). Our data show that, in contrast to RTE, CD44(v.low) cells express high levels of CD45RB and low levels of CD24. Moreover, CD44(v.low) cells isolated from mice devoid of RTE retain their capacity to repopulate lymphopenic mice with naïve and memory cells and Foxp3(+) Tregs. In addition, CD44(v.low) cells do not express IL-2Rβ, Sca-1, and CXCR3, the phenotypic hallmarks of T(SCM). Overall, these data demonstrate that CD44(v.low) cells are neither RTE nor T(SCM).

Indexed as

Adoptive TransferAnimalsAntigens, LyBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementForkhead Transcription FactorsGene ExpressionHyaluronan ReceptorsImmunologic MemoryInterleukin-2 Receptor beta SubunitLeukocyte Common AntigensLymphopeniaMembrane ProteinsMiceAntigens, LyBiomarkersCd44 protein, mouseCxcr3 protein, mouseForkhead Transcription FactorsFoxp3 protein, mouseHyaluronan ReceptorsIl2rb protein, mouseInterleukin-2 Receptor beta SubunitLeukocyte Common AntigensLy6a protein, mouseMembrane ProteinsReceptors, CXCR3CytokinesImmune homeostasisPrecursor cellsRecent thymic emigrants (RTE)Stem cell-like memory cells (T(SCM))T cell subsets

Identifiers

PMID25910642
PMCPMC4509828
OpenAlexW1977261327

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.