Evidence map›Paper›PMID 25910482›Full record

ReviewVirologica Sinica2015

Recent advances in the study of HPV-associated carcinogenesis.

Liyan Jin, Zhi-Xiang Xu

Abstract readReview
In one paragraph

Review in Virologica Sinica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Liyan JinDivision of Hematology and Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, 35205, USA.
Zhi-Xiang Xu
University of Alabama at Birmingham · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI Richard Bruce Roden · 2003 to 2026
$53.5M
The UAB Sexually Transmitted Infections Cooperative Research Centers (STI CRC)U19AI113212 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HOOK, EDWARD W · 2014 to 2018
$10.0M
The role of LKB1 in the maintenance of genomic stability.R01CA133053 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI XU, ZHI-XIANG · 2009 to 2013
$1.2M
NCI NIH HHS P30 CA013148NCI NIH HHS P50 CA098252NCI NIH HHS P50CA098252NCI NIH HHS R01 CA133053NCI NIH HHS R01CA133053NIAID NIH HHS U19 AI 113212NIAID NIH HHS U19 AI113212
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) cause virtually all cervical cancers, the second leading cause of death by cancer among women, as well as other anogenital cancers and a subset of head and neck cancers. Approximately half of women, who develop cervical cancer die from it. Despite the optimism that has accompanied the introduction of prophylactic vaccines to prevent some HPV infections, the relatively modest uptake of the vaccine, especially in the developing world, and the very high fraction of men and women who are already infected, means that HPV-associated disease will remain as a significant public health problem for decades. In this review, we summarize some recent findings on HPV-associated carcinogenesis, such as miRNAs in HPV-associated cancers, implication of stem cells in the biology and therapy of HPV-positive cancers, HPV vaccines, targeted therapy of cervical cancer, and drug treatment for HPV-induced intraepithelial neoplasias.

Indexed as

CarcinogenesisHost-Pathogen InteractionsHumansNeoplasmsPapillomaviridae

Identifiers

PMID25910482
PMCPMC4431587
OpenAlexW2099907118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.