ArticleChemistry & biology2015
Small molecule fluoride toxicity agonists.
Article in Chemistry & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Lipophilic mono-guanidinesRSC advances · 2026Article
- Fluoride triggers lysis inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Enhancement of Fluoride's Antibacterial and Antibiofilm Effects against OralAntibiotics (Basel, Switzerland) · 2024Article
- The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis.Nature communications · 2024Review
- Lanthanum-fluoride electrode-based methods to monitor fluoride transport in cells and reconstituted lipid vesicles.Methods in enzymology · 2024Article
- Screening for small molecule inhibitors of SAH nucleosidase using an SAH riboswitch.Analytical biochemistry · 2023Article
- Discovering riboswitches: the past and the future.Trends in biochemical sciences · 2023Review
- Diarylureas: New Promising Small Molecules againstAntibiotics (Basel, Switzerland) · 2023Review
- Microwell Fluoride Screen for Chemical, Enzymatic, and Cellular Reactions Reveals Latent Microbial Defluorination Capacity for -CFApplied and environmental microbiology · 2022Article
- Nothing lasts forever: understanding microbial biodegradation of polyfluorinated compounds and perfluorinated alkyl substances.Microbial biotechnology · 2022Review
- Novel urea derivative-loaded PLGA nanoparticles to inhibit caries-associatedRSC advances · 2022Article
- Diaryl Urea Derivative Molecule Inhibits CariogenicFrontiers in cellular and infection microbiology · 2022Article
- A bacterial riboswitch class senses xanthine and uric acid to regulate genes associated with purine oxidation.RNA (New York, N.Y.) · 2020Article
- High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch.Molecules (Basel, Switzerland) · 2020Article
- Employing a ZTP Riboswitch to Detect Bacterial Folate Biosynthesis Inhibitors in a Small Molecule High-Throughput Screen.ACS chemical biology · 2019Article
- A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer.eLife · 2019Article
- Rare variants of the FMN riboswitch class inRNA (New York, N.Y.) · 2019Article
- An Archaeal Fluoride-Responsive Riboswitch Provides an Inducible Expression System for Hyperthermophiles.Applied and environmental microbiology · 2018Article
- An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Fluoride is a ubiquitous anion that inhibits a wide variety of metabolic processes. Here, we report the identification of a series of compounds that enhance fluoride toxicity in Escherichia coli and Streptococcus mutans. These molecules were isolated by using a high-throughput screen (HTS) for compounds that increase intracellular fluoride levels as determined via a fluoride riboswitch reporter fusion construct. A series of derivatives were synthesized to examine structure-activity relationships, leading to the identification of compounds with improved activity. Thus, we demonstrate that small molecule fluoride toxicity agonists can be identified by HTS from existing chemical libraries by exploiting a natural fluoride riboswitch. In addition, our findings suggest that some molecules might be further optimized to function as binary antibacterial agents when combined with fluoride.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.