Evidence map›Paper›PMID 25910237›Full record

ArticleChemistry & biology2015

Tackling oxidative stress by a direct route: a new job for HDAC inhibitors?

Luca Sartori, Saverio Minucci

Abstract readComment
PubMed Publisher
In one paragraph

Article in Chemistry & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Hypothesis: role for ammonia neutralization in the prevention and reversal of heart failure.American journal of physiology. Heart and circulatory physiology · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Luca SartoriDepartment of Experimental Oncology, Academic Drug Discovery Program, and Drug Development Program, European Institute of Oncology, Via Adamello, Milan 20139, Italy.
Saverio MinucciDepartment of Experimental Oncology, Academic Drug Discovery Program, and Drug Development Program, European Institute of Oncology, Via Adamello, Milan 20139, Italy; Department of Biosciences, University of Milan, Via Celoria 26, Milan 20100, Italy. Electronic address: saverio.minucci@ieo.eu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olson et al. (2015) propose that some hydroxamic acid-based small molecules, already in clinical use as histone deacetylase inhibitors, may protect against oxidative stress through a direct chemical reaction of dismutation of hydrogen peroxide into water.

Indexed as

AnimalsHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic AcidsNeuronsHistone Deacetylase InhibitorsHistone DeacetylasesHydroxamic Acids

Identifiers

PMID25910237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.