ArticlePLoS computational biology2015
Existence and control of Go/No-Go decision transition threshold in the striatum.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- First steps matter: gait initiation reveals emotion-driven motor compensation in Parkinson's disease.Brain communications · 2025Article
- Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states.Cognitive neurodynamics · 2024Article
- Computational insights on asymmetricalCognitive neurodynamics · 2024Article
- A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive-compulsive disorder.Cognitive neurodynamics · 2023Article
- Bayesian Mapping of the Striatal Microcircuit Reveals Robust Asymmetries in the Probabilities and Distances of Connections.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Repetitive Restricted Behaviors in Autism Spectrum Disorder: From Mechanism to Development of Therapeutics.Frontiers in neuroscience · 2022Review
- A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection.The European journal of neuroscience · 2021Article
- The microcircuits of striatum in silico.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Auditory Long-Range Parvalbumin Cortico-Striatal Neurons.Frontiers in neural circuits · 2020Article
- Biased competition in the absence of input bias revealed through corticostriatal computation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Errors in Action Timing and Inhibition Facilitate Learning by Tuning Distinct Mechanisms in the Underlying Decision Process.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Exploring the role of striatal D1 and D2 medium spiny neurons in action selection using a virtual robotic framework.The European journal of neuroscience · 2019Article
- Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2.Frontiers in neural circuits · 2018Review
- A Pause-then-Cancel model of stopping: evidence from basal ganglia neurophysiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Interplay between periodic stimulation and GABAergic inhibition in striatal network oscillations.PloS one · 2017Article
- The role of cortical oscillations in a spiking neural network model of the basal ganglia.PloS one · 2017Article
- Forgetting in Reinforcement Learning Links Sustained Dopamine Signals to Motivation.PLoS computational biology · 2016Article
- Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.Frontiers in neural circuits · 2016Article
- Believer-Skeptic Meets Actor-Critic: Rethinking the Role of Basal Ganglia Pathways during Decision-Making and Reinforcement Learning.Frontiers in neuroscience · 2016Article
- Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures.PLoS computational biology · 2015Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A typical Go/No-Go decision is suggested to be implemented in the brain via the activation of the direct or indirect pathway in the basal ganglia. Medium spiny neurons (MSNs) in the striatum, receiving input from cortex and projecting to the direct and indirect pathways express D1 and D2 type dopamine receptors, respectively. Recently, it has become clear that the two types of MSNs markedly differ in their mutual and recurrent connectivities as well as feedforward inhibition from FSIs. Therefore, to understand striatal function in action selection, it is of key importance to identify the role of the distinct connectivities within and between the two types of MSNs on the balance of their activity. Here, we used both a reduced firing rate model and numerical simulations of a spiking network model of the striatum to analyze the dynamic balance of spiking activities in D1 and D2 MSNs. We show that the asymmetric connectivity of the two types of MSNs renders the striatum into a threshold device, indicating the state of cortical input rates and correlations by the relative activity rates of D1 and D2 MSNs. Next, we describe how this striatal threshold can be effectively modulated by the activity of fast spiking interneurons, by the dopamine level, and by the activity of the GPe via pallidostriatal backprojections. We show that multiple mechanisms exist in the basal ganglia for biasing striatal output in favour of either the `Go' or the `No-Go' pathway. This new understanding of striatal network dynamics provides novel insights into the putative role of the striatum in various behavioral deficits in patients with Parkinson's disease, including increased reaction times, L-Dopa-induced dyskinesia, and deep brain stimulation-induced impulsivity.
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