A genetic clog in the vitamin A transport machinery.

Ming Zhong, Hui Sun

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6.Membranes · 2015
Review

4 · The record

Corrections and comments

Comment on
Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease.2015

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ming ZhongHoward Hughes Medical Institute, Department of Physiology and Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, U.S.A.

Hui SunHoward Hughes Medical Institute, Department of Physiology and Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, U.S.A. Electronic address: hsun@mednet.ucla.edu.

Howard Hughes Medical Institute · US

Funding

Molecular Mechanism of Vitamin A Uptake for VisionR01EY018144 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, HUI · 2007 to 2017

$3.1M

Howard Hughes Medical InstituteNEI NIH HHS R01 EY018144

6 · The paper itself

Abstract

Chou et al. discover a new mode of maternal inheritance by analyzing human mutations in plasma retinol binding protein (RBP). Mechanistically, these mutations simultaneously lower RBP's affinity for vitamin A and greatly increase its affinity for its cell-surface receptor, thus dominantly blocking the transmembrane transport of vitamin A.

Indexed as

Mutation, MissenseAnimalsEye Diseases, HereditaryFemaleHumansMalePregnancyRetinol-Binding Proteins, PlasmaRetinol-Binding Proteins, Plasma

Identifiers

PMID25910203

DOI10.1016/j.cell.2015.04.020

OpenAlexW2063375049

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.