Evidence map›Paper›PMID 25909888›Full record

ArticleCell death and differentiation2016

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.

B Oettinghaus, J M Schulz, L M Restelli, M Licci, C Savoia, A Schmidt, K Schmitt, A Grimm, L Morè, J Hench and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 137 citations in OpenAlex.

  1. Review
  2. Mitochondrial molecular diversity in the brain.Current opinion in neurobiology · 2026
    Review
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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 3 countries.

B OettinghausDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
J M SchulzDivision of Neurophysiology, Institute of Physiology, Department of Biomedicine, University of Basel, Basel 4056, Switzerland.
L M RestelliDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
M LicciDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
C SavoiaDepartment of Biology, University of Padua, Padua 35121, Italy.
A SchmidtProteomics Core Facility, Biozentrum, University of Basel, Basel 4056, Switzerland.
K SchmittNeurobiology Laboratory for Brain and Mental Health, University Psychiatric University Clinics Basel, University of Basel, Basel 4012, Switzerland.
A GrimmNeurobiology Laboratory for Brain and Mental Health, University Psychiatric University Clinics Basel, University of Basel, Basel 4012, Switzerland.
L MorèDulbecco Telethon Institute IRCCS, San Raffaele Scientific Institute, Milan 20132, Italy.
J HenchDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
M TolnayDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
A EckertNeurobiology Laboratory for Brain and Mental Health, University Psychiatric University Clinics Basel, University of Basel, Basel 4012, Switzerland.
P D'AdamoDulbecco Telethon Institute IRCCS, San Raffaele Scientific Institute, Milan 20132, Italy.
P FrankenFaculty of Biology and Medicine, Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland.
N IshiharaDepartment of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume 839-0864, Japan.
K MiharaDepartment of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume 839-0864, Japan.
J BischofbergerDivision of Neurophysiology, Institute of Physiology, Department of Biomedicine, University of Basel, Basel 4056, Switzerland.
L ScorranoDepartment of Biology, University of Padua, Padua 35121, Italy.
S FrankDivision of Neuropathology, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland.
University Hospital of Basel · CHUniversity of Basel · CHIstituti di Ricovero e Cura a Carattere Scientifico · ITKurume University · JPUniversity of Lausanne · CHUniversity of Padua · ITVeneto Institute of Molecular Medicine · IT

Funding

Telethon TCR12001
6 · The paper itself

Abstract

Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal early during embryonic development or around birth, but the role of mitochondrial fission in adult neurons remains unclear. Here we show that inducible Drp1 ablation in neurons of the adult mouse forebrain results in progressive, neuronal subtype-specific alterations of mitochondrial morphology in the hippocampus that are marginally responsive to antioxidant treatment. Furthermore, DRP1 loss affects synaptic transmission and memory function. Although these changes culminate in hippocampal atrophy, they are not sufficient to cause neuronal cell death within 10 weeks of genetic Drp1 ablation. Collectively, our in vivo observations clarify the role of mitochondrial fission in neurons, demonstrating that Drp1 ablation in adult forebrain neurons compromises critical neuronal functions without causing overt neurodegeneration.

Indexed as

AnimalsAntioxidantsAtrophyDynaminsHippocampusMemory DisordersMiceMitochondriaMitochondrial DynamicsNerve DegenerationNervous SystemNeuronsProsencephalonAntioxidantsDnm1l protein, mouseDynamins

Identifiers

PMID25909888
PMCPMC4815974
OpenAlexW2026709267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.