Evidence map›Paper›PMID 25909857›Full record

ArticlePloS one2015

Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells.

Kwangseon Jung, Jae Youl Cho, Young-Jin Soh, Jienny Lee, Seoung Woo Shin, Sunghee Jang, Eunsun Jung, Min Hee Kim, Jongsung Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kwangseon JungDepartment of Convergence Biomedical Science & Engineering, Eulji University, Seongnam City, Gyunggi Do, Republic of Korea; Skincure Life Science Institute, Seongnam City, Gyunggi Do, Republic of Korea.
Jae Youl ChoDepartment of Genetic Engineering, Sungkyunkwan University, Suwon-Si, Gyeonggi-Do, Republic of Korea.
Young-Jin SohDepartment of Dermatological Health Management, College of Health Science, Eulji University, Seongnam City, Gyunggi Do, Korea.
Jienny LeeViral Disease Division, Animal and Plant Quarantine Agency, 175 Anyang-Ro, Manan-Gu, Anyang-Si, Gyeonggi-Do, Republic of Korea.
Seoung Woo ShinBiospectrum Life Science Institute, Seongnam City, Gyunggi Do, Republic of Korea.
Sunghee JangDepartment of Senior Healthcare, BK21 plus program, Graduated school, Eulji University, Seongnam City, Gyunggi Do, Republic of Korea.
Eunsun JungBiospectrum Life Science Institute, Seongnam City, Gyunggi Do, Republic of Korea.
Min Hee KimDepartment of Physical Therapy, College of Health Science, Eulji University, Seongnam City, Gyunggi Do, Republic of Korea.
Jongsung LeeDepartment of Convergence Biomedical Science & Engineering, Eulji University, Seongnam City, Gyunggi Do, Republic of Korea; Department of Senior Healthcare, BK21 plus program, Graduated school, Eulji University, Seongnam City, Gyunggi Do, Republic of Korea.
Eulji University · KRSungkyunkwan University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet A (UVA) irradiation is responsible for a variety of changes in cell biology. The purpose of this study was to investigate effects of aspartic acid on UVA irradiation-induced damages in the stemness properties of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Furthermore, we elucidated the UVA-antagonizing mechanisms of aspartic acid. The results of this study showed that aspartic acid attenuated the UVA-induced reduction of the proliferative potential and stemness of hAMSCs, as evidenced by increased proliferative activity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and upregulation of stemness-related genes OCT4, NANOG, and SOX2 in response to the aspartic acid treatment. UVA-induced reduction in the mRNA level of hypoxia-inducible factor (HIF)-1α was also significantly recovered by aspartic acid. In addition, the antagonizing effects of aspartic acid against the UVA effects were found to be mediated by reduced production of PGE2 through the inhibition of JNK and p42/44 MAPK. Taken together, these findings show that aspartic acid improves reduced stemness of hAMSCs induced by UVA and its effects are mediated by upregulation of HIF-1α via the inhibition of PGE2-cAMP signaling. In addition, aspartic acid may be used as an antagonizing agent to mitigate the effects of UVA.

Indexed as

Adipose TissueArabidopsis ProteinsAspartic AcidCell ProliferationCells, CulturedCyclic AMPDinoprostoneDown-RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitIntramolecular TransferasesMAP Kinase Signaling SystemMesenchymal Stem CellsTranscription Factor AP-1Ultraviolet RaysArabidopsis ProteinsAspartic AcidCyclic AMPDinoprostoneHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitIntramolecular Transferasesmarneral synthase, ArabidopsisTranscription Factor AP-1

Identifiers

PMID25909857
PMCPMC4409053
OpenAlexW1982395999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.