ArticlePloS one2015
Reduced Haemodynamic Response in the Ageing Visual Cortex Measured by Absolute fNIRS.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- A Systematic Review of the Application of Functional Near-Infrared Spectroscopy to the Study of Cerebral Hemodynamics in Healthy Aging.Neuropsychology review · 2021Pooled it
- Monitoring the haemodynamic response to visual stimulation in glaucoma patients.Scientific reports · 2021Trial
- The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training.bioRxiv : the preprint server for biology · 2025Article
- fNIRS as a biomarker for X-linked neurodevelopmental disorders: leveraging visual processing to assess brain function?Frontiers in neuroscience · 2025Article
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Revealing the Spatial Pattern of Brain Hemodynamic Sensitivity to Healthy Aging through Sparse Dynamic Causal Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Ultrasound Flow Imaging Study on Rat Brain with Ultrasound and Light Stimulations.Bioengineering (Basel, Switzerland) · 2024Article
- Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- The amplitude of fNIRS hemodynamic response in the visual cortex unmasks autistic traits in typically developing children.Translational psychiatry · 2022Article
- Hemodynamic Response to Three Types of Urban Spaces before and after Lockdown during the COVID-19 Pandemic.International journal of environmental research and public health · 2021Article
- Investigating the effects of healthy cognitive aging on brain functional connectivity using 4.7 T resting-state functional magnetic resonance imaging.Brain structure & function · 2021Review
- Model-Predicted Balance Between Neural Excitation and Inhibition Was Maintained Despite of Age-Related Decline in Sensory Evoked Local Field Potential in Rat Barrel Cortex.Frontiers in systems neuroscience · 2020Article
- Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2020Review
- Age-variant and age-invariant features of functional brain organization in middle-aged and older autistic adults.Molecular autism · 2020Article
- Measuring visual cortical oxygenation in diabetes using functional near-infrared spectroscopy.Acta diabetologica · 2018Article
- Age-Related Changes in Global Motion Coherence: Conflicting Haemodynamic and Perceptual Responses.Scientific reports · 2018Article
- Working memory, age and education: A lifespan fMRI study.PloS one · 2018Article
- BOLD neurovascular coupling does not change significantly with normal aging.Human brain mapping · 2017Article
- Linking cognitive and visual perceptual decline in healthy aging: The information degradation hypothesis.Neuroscience and biobehavioral reviews · 2016Review
- Using Functional Near Infrared Spectroscopy (fNIRS) to Study Dynamic Stereoscopic Depth Perception.Brain topography · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of healthy ageing on visual cortical activation is still to be fully explored. This study aimed to elucidate whether the haemodynamic response (HDR) of the visual cortex altered as a result of ageing. Visually normal (healthy) participants were presented with a simple visual stimulus (reversing checkerboard). Full optometric screening was implemented to identify two age groups: younger adults (n = 12, mean age 21) and older adults (n = 13, mean age 71). Frequency-domain Multi-distance (FD-MD) functional Near-Infrared Spectroscopy (fNIRS) was used to measure absolute changes in oxygenated [HbO] and deoxygenated [HbR] haemoglobin concentrations in the occipital cortices. Utilising a slow event-related design, subjects viewed a full field reversing checkerboard with contrast and check size manipulations (15 and 30 minutes of arc, 50% and 100% contrast). Both groups showed the characteristic response of increased [HbO] and decreased [HbR] during stimulus presentation. However, older adults produced a more varied HDR and often had comparable levels of [HbO] and [HbR] during both stimulus presentation and baseline resting state. Younger adults had significantly greater concentrations of both [HbO] and [HbR] in every investigation regardless of the type of stimulus displayed (p<0.05). The average variance associated with this age-related effect for [HbO] was 88% and [HbR] 91%. Passive viewing of a visual stimulus, without any cognitive input, showed a marked age-related decline in the cortical HDR. Moreover, regardless of stimulus parameters such as check size, the HDR was characterised by age. In concurrence with present neuroimaging literature, we conclude that the visual HDR decreases as healthy ageing proceeds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.