Trial reportJournal of hypertension2015
Are two commonly used self-report questionnaires useful for identifying antihypertensive medication nonadherence?
Trial report in Journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01257347 (Uncontrolled Hypertension), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Uncontrolled Hypertension: The Role of Medication Adherence and Clinical Inertia
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Measurement Properties of Patient-Reported Outcome Measures for Medication Adherence in Cardiovascular Disease: A COSMIN Systematic Review.Clinical drug investigation · 2022Pooled it
- Global Burden, Regional Differences, Trends, and Health Consequences of Medication Nonadherence for Hypertension During 2010 to 2020: A Meta-Analysis Involving 27 Million Patients.Journal of the American Heart Association · 2022Pooled it
- Questionnaires on adherence to antihypertensive treatment: a systematic review of published questionnaires and their psychometric properties.International journal of clinical pharmacy · 2020Pooled it
- The Association Between Antihypertensive Medication Nonadherence and Visit-to-Visit Variability of Blood Pressure: Findings From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- A multi-component, family-focused and literacy-sensitive intervention to improve medication adherence in patients with heart failure-A randomized controlled trial.Heart & lung : the journal of critical careTrial
- Medication Non-Adherence in Resistant Hypertension: Detection, Drivers, and Practical Solutions.Current cardiology reports · 2026Review
- Adherence to oral antineoplastic therapy among patients with advanced or metastatic non-small cell lung cancer: a noninterventional, prospective study.Journal of cancer research and clinical oncology · 2025Observational
- Medication adherence scales in non-communicable diseases: A scoping review of design gaps, constructs and validation processes.PloS one · 2025Article
- Association Between Self-Reported Medication Adherence and Therapeutic Inertia in Hypertension: A Secondary Analysis of SPRINT (Systolic Blood Pressure Intervention Trial).Journal of the American Heart Association · 2024Article
- Patient-Reported Reasons for Antihypertensive Medication Change: A Quantitative Study Using Social Media.Drug safety · 2024Article
- Assessment of adherence to statin therapy in patients with coronary artery disease: comparison of three self-reporting measures.European journal of hospital pharmacy : science and practice · 2023Article
- Study design of BETTER-BP: Behavioral economics trial to enhance regulation of blood pressure.International journal of cardiology. Cardiovascular risk and prevention · 2022Article
- Prevalence and biopsychosocial factors associated with treatment adherence among people with epilepsy in a tertiary care hospital in Riyadh, Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2022Observational
- Smart About Meds (SAM): a pilot randomized controlled trial of a mobile application to improve medication adherence following hospital discharge.JAMIA open · 2021Article
- Measuring the multiple domains of medication nonadherence: findings from a Delphi survey of adherence experts.Translational behavioral medicine · 2021Article
- The Nexus Between Adherence to Recommended Lifestyle Behaviors and Blood Pressure Control in Hypertensive Patients at Mutare Provincial Hospital, Zimbabwe: A Cross-Sectional Study.Patient preference and adherence · 2021Article
- The use of an electronic medication organizer device with alarm to improve medication adherence of older adults with hypertension.Einstein (Sao Paulo, Brazil) · 2021Article
- Association of Self-Reported Medication Adherence with Potentially Inappropriate Medications in Elderly Patients: A Cross-Sectional Pilot Study.International journal of environmental research and public health · 2020Article
- Medication Adherence to Antihypertensive Triple-Combination Therapy Among Patients Enrolled in a Medicare Advantage Plan.Journal of managed care & specialty pharmacy · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveMedication nonadherence is a major cause of uncontrolled hypertension, but clinicians are poor at judging adherence, and the gold standard for measuring adherence, electronic monitoring, is rarely available in clinical settings. Self-report questionnaires (SRQs), by contrast, are inexpensive, easy to administer, and hence, may be useful for 'diagnosing' nonadherence. In this study, we evaluated the validity of two commonly used medication adherence SRQs among patients with uncontrolled hypertension, using electronic pillbox measurement as the gold standard.
methodsA total of 149 patients with uncontrolled hypertension had adherence to their antihypertensive medication regimen monitored using a four-compartment electronic pillbox (MedSignals) between two primary care visits (median 50 days). Participants completed the 8-item Morisky Medication Adherence Scale (MMAS-8) and the Visual Analog Scale (VAS) at the second visit. Likelihood ratios were calculated using less than 80% correct dosing adherence by electronic measurement as the gold standard.
resultsSRQ scores indicating low adherence (MMAS-8 <6 and VAS <80%, 23 and 9% of participants, respectively) had likelihood ratios of 2.00 [95% confidence interval (CI) 1.10-3.65] and 7.72 (95% CI 1.77-33.6), respectively, for detecting nonadherence compared to electronic measurement. SRQ scores indicating highest adherence (MMAS-8 = 8 and VAS = 100%, 43 and 61% of participants, respectively) had likelihood ratios of 0.55 (95% CI 0.35-0.85) and 0.76 (95% CI 0.57-1.01), respectively, for detecting nonadherence.
conclusionThe MMAS-8 and VAS are modestly useful in identifying antihypertensive medication nonadherence. Other tools, including electronic measurement, may be needed to guide titration of antihypertensive medications among patients with uncontrolled hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.