ArticleScientific reports2015
Droplet-interface-bilayer assays in microfluidic passive networks.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 59 citations in OpenAlex.
- Multi-Material Droplet-Based Hydrogel Threads for Extrusion 3D Printing.Small methods · 2026Article
- Microrail-assisted liposome trapping and aligning in microfluidic channels.RSC advances · 2024Article
- Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2.The Journal of cell biology · 2022Article
- Vision-Based Performance Analysis of an Active Microfluidic Droplet Generation System Using Droplet Images.Sensors (Basel, Switzerland) · 2022Article
- Challenges and opportunities in achieving the full potential of droplet interface bilayers.Nature chemistry · 2022Review
- Investigating the effect of phospholipids on droplet formation and surface property evolution in microfluidic devices for droplet interface bilayer (DIB) formation.Biomicrofluidics · 2022Article
- Permeation Studies across Symmetric and Asymmetric Membranes in Microdroplet Arrays.Analytical chemistry · 2021Article
- Microdroplet Operations in Polymeric Microtubes.Analytical chemistry · 2021Article
- Microfluidic platform enables tailored translocation and reaction cascades in nanoliter droplet networks.Communications biology · 2020Article
- Microfluidic Formation of Honeycomb-Patterned Droplets Bounded by Interface Bilayers via Bimodal Molecular Adsorption.Micromachines · 2020Article
- Microfluidic fabrication of microparticles for biomedical applications.Chemical Society reviews · 2018Review
- In vitro synthesis of a Major Facilitator Transporter for specific active transport across Droplet Interface Bilayers.Scientific reports · 2016Article
- Droplet Merging on a Lab-on-a-Chip Platform by Uniform Magnetic Fields.Scientific reports · 2016Article
- Formation of droplet interface bilayers in a Teflon tube.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basic biophysical studies and pharmacological processes can be investigated by mimicking the intracellular and extracellular environments across an artificial cell membrane construct. The ability to reproduce in vitro simplified scenarios found in live cell membranes in an automated manner has great potential for a variety of synthetic biology and compound screening applications. Here, we present a fully integrated microfluidic system for the production of artificial lipid bilayers based on the miniaturisation of droplet-interface-bilayer (DIB) techniques. The platform uses a microfluidic design that enables the controlled positioning and storage of phospholipid-stabilized water-in-oil droplets, leading successfully to the scalable and automated formation of arrays of DIBs to mimic cell membrane processes. To ensure robustness of operation, we have investigated how lipid concentration, immiscible phase flow velocities and the device geometrical parameters affect the system performance. Finally, we produced proof-of-concept data showing that diffusive transport of molecules and ions across on-chip DIBs can be studied and quantified using fluorescence-based assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.