ArticlePloS one2015
Regulation of Cadmium-Induced Proteomic and Metabolic Changes by 5-Aminolevulinic Acid in Leaves of Brassica napus L.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 162 citations in OpenAlex.
- Role of Serotonin in Cadmium Mitigation in Plants.Plants (Basel, Switzerland) · 2025Review
- 5-Aminolevulinic acid treatment mitigates pesticide stress in bean seedlings by regulating stress-related gene expression and retrotransposon movements.Protoplasma · 2024Article
- Review
- Exogenously applied 5-aminolevulinic acid modulates growth, yield, and physiological parameters in lentil (Lens culinaris Medik.) under rain-fed and supplemental irrigation conditions.Scientific reports · 2023Article
- Metabolic Regulation and Lipidomic Remodeling in Relation to Spermidine-induced Stress Tolerance to High Temperature in Plants.International journal of molecular sciences · 2022Article
- Alleviation of cadmium phytotoxicity through melatonin modulated physiological functions, antioxidants, and metabolites in tomato (Solanum lycopersicum L.).Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Transcriptome Analysis Reveals the Stress Tolerance to and Accumulation Mechanisms of Cadmium inPlants (Basel, Switzerland) · 2022Article
- Foliar application of Zinc oxide nanoparticles alleviates cadmium toxicity in purslane by maintaining nutrients homeostasis and improving the activity of antioxidant enzymes and glyoxalase system.Ecotoxicology (London, England) · 2022Article
- Zinc oxide nanoparticles improve lettuce (Frontiers in plant science · 2022Article
- The Impact of Bio-Stimulants on Cd-Stressed Wheat (Frontiers in plant science · 2022Article
- Article
- Both uniconazole and 5-aminolevulinic acid increase maize (Photosynthetica · 2022Article
- Amassing of heavy metals in soils, vegetables and crop plants irrigated with wastewater: Health risk assessment of heavy metals in Dera Ghazi Khan, Punjab, Pakistan.Frontiers in plant science · 2022Article
- Synergistic Effect of Zinc Oxide Nanoparticles andFrontiers in plant science · 2022Article
- Role of phytomelatonin responsive to metal stresses: An omics perspective and future scenario.Frontiers in plant science · 2022Review
- Association of jasmonic acid priming with multiple defense mechanisms in wheat plants under high salt stress.Frontiers in plant science · 2022Article
- Cadmium Phytotoxicity, Tolerance, and Advanced Remediation Approaches in Agricultural Soils; A Comprehensive Review.Frontiers in plant science · 2022Review
- Physiological Mechanism of Exogenous 5-Aminolevulinic Acid Improved the Tolerance of Chinese Cabbage (Frontiers in plant science · 2022Article
- Alleviation of Lead Stress on Sage Plant by 5-Aminolevulinic Acid (ALA).Plants (Basel, Switzerland) · 2021Article
- 5-aminolevulinic acid-mediated plant adaptive responses to abiotic stress.Plant cell reports · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is evident from previous reports that 5-aminolevulinic acid (ALA), like other known plant growth regulators, is effective in countering the injurious effects of heavy metal-stress in oilseed rape (Brassica napus L.). The present study was carried out to explore the capability of ALA to improve cadmium (Cd2+) tolerance in B. napus through physiological, molecular, and proteomic analytical approaches. Results showed that application of ALA helped the plants to adjust Cd2+-induced metabolic and photosynthetic fluorescence changes in the leaves of B. napus under Cd2+ stress. The data revealed that ALA treatment enhanced the gene expressions of antioxidant enzyme activities substantially and could increase the expression to a certain degree under Cd2+ stress conditions. In the present study, 34 protein spots were identified that differentially regulated due to Cd2+ and/or ALA treatments. Among them, 18 proteins were significantly regulated by ALA, including the proteins associated with stress related, carbohydrate metabolism, catalysis, dehydration of damaged protein, CO2 assimilation/photosynthesis and protein synthesis/regulation. From these 18 ALA-regulated proteins, 12 proteins were significantly down-regulated and 6 proteins were up-regulated. Interestingly, it was observed that ALA-induced the up-regulation of dihydrolipoyl dehydrogenase, light harvesting complex photo-system II subunit 6 and 30S ribosomal proteins in the presence of Cd2+ stress. In addition, it was also observed that ALA-induced the down-regulation in thioredoxin-like protein, 2, 3-bisphosphoglycerate, proteasome and thiamine thiazole synthase proteins under Cd2+ stress. Taken together, the present study sheds light on molecular mechanisms involved in ALA-induced Cd2+ tolerance in B. napus leaves and suggests a more active involvement of ALA in plant physiological processes than previously proposed.
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