Evidence map›Paper›PMID 25909448›Full record

ArticleAnnals of the American Thoracic Society2015

Vigorous Exercise Can Cause Abnormal Pulmonary Function in Healthy Adolescents.

Alladdin Abosaida, Jen Jen Chen, Eliezer Nussbaum, Szu-Yun Leu, Terry Chin, Christina D Schwindt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alladdin Abosaida1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.
Jen Jen Chen1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.ORCID http://orcid.org/0000-0002-5628-8977
Eliezer Nussbaum1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.
Szu-Yun Leu1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.
Terry Chin1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.
Christina D Schwindt1 Department of Pediatrics, School of Medicine, University of California, Irvine (UC Irvine), Irvine, California.
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Peripheral Blood Mononuclear Cells, Exercise, and Children: Initial MechanismsP01HD048721 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2006 to 2016
$13.6M
U.C. Irvine Multidisciplinary Exercise Science Training ProgramT32AR047752 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, COOPER, DAN M · 2003 to 2018
$2.5M
Exercise, Pollution, and Neutrophils in Pediatric AsthmaK23ES014923 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SCHWINDT, CHRISTINA DANELL · 2006 to 2010
$708k
NCATS NIH HHS UL1 TR001414NCRR NIH HHS UL1RR03198NIAMS NIH HHS T32 AR047752NICHD NIH HHS P01 HD048721NIEHS NIH HHS K23 ES014923
6 · The paper itself

Abstract

rationaleAlthough exercise-induced bronchoconstriction is more common in adolescents with asthma, it also manifests in healthy individuals without asthma. The steady-state exercise protocol is widely used and recommended by the American Thoracic Society (ATS) as a method to diagnose exercise-induced bronchoconstriction. Airway narrowing in response to exercise is thought to be related to airway wall dehydration secondary to hyperventilation. More rigorous exercise protocols may have a role in detecting exercise-induced bronchoconstriction in those who otherwise have a normal response to steady-state exercise challenge.

objectivesThe objective of this study was to determine the effect of two different exercise protocols--a constant work rate protocol and a progressive ramp protocol--on pulmonary function testing in healthy adolescents. We hypothesized that vigorous exercise protocols would lead to reductions in lung function in healthy adolescents.

methodsA total of 56 healthy adolescents (mean age, 15.2 ± 3.3 [SD] years) were recruited to perform two exercise protocols: constant work rate exercise test to evaluate for exercise-induced bronchoconstriction (as defined by ATS) and standardized progressive ramp protocol. Pulmonary function abnormalities were defined as a decline from baseline in FEV1 of greater than 10%. MEASUREMENTS AND MAIN

resultsTen participants (17.8%) had a significant drop in FEV1. Among those with abnormal lung function after exercise, three (30%) were after the ATS test only, five (50%) were after the ramp test only, and two (20%) were after both ATS and ramp tests.

conclusionHealthy adolescents demonstrate subtle bronchoconstriction after exercise. This exercise-induced bronchoconstriction may be detected in healthy adolescents via constant work rate or the progressive ramp protocol. In a clinical setting, ramp testing warrants consideration in adolescents suspected of having exercise-induced bronchoconstriction and who have normal responses to steady-state exercise testing.

Indexed as

AdolescentBronchoconstrictionExerciseExercise TestFemaleHealthy VolunteersHumansMaleRespiratory Function Testsexercise-induced bronchoconstrictionexercise physiologyexercise testing

Identifiers

PMID25909448
PMCPMC4590023
OpenAlexW1975322888

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.