Trial reportPloS one2015
Randomized controlled trial of a mobile phone intervention for improving adherence to naltrexone for alcohol use disorders.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01349985 (SBIR-PhaseII, "Adaptive Goal-Directed Adherence Tracking and Enhancement"), which is not on this map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SBIR-PhaseII, "Adaptive Goal-Directed Adherence Tracking and Enhancement"
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Effectiveness of Alcohol Use Disorder Pharmacotherapies by Sex: Systematic Review and Meta-Analysis.Drug and alcohol review · 2026Pooled it
- The rates and measurement of adherence to acamprosate in randomised controlled clinical trials: A systematic review.PloS one · 2022Pooled it
- The Effectiveness of Mobile Phone-Based Text Messaging to Intervene with Problem Drinking in Youth and Younger Adult Population: A Meta-Analysis.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2020Pooled it
- Measures of Effectiveness, Efficiency, and Quality of Telemedicine in the Management of Alcohol Abuse, Addiction, and Rehabilitation: Systematic Review.Journal of medical Internet research · 2020Pooled it
- Feasibility and Effects of Digital Interventions to Support People in Recovery From Substance Use Disorders: Systematic Review.Journal of medical Internet research · 2018Pooled it
- Correlates of post-hospitalization naltrexone adherence for alcohol use disorder.Drug and alcohol dependence · 2024Trial
- Naltrexone and Nalmefene as Modern Psychopharmacotherapy for Alcohol Use Disorder: Modulation of Opioid Receptors and Neurobiological Pathways of Alcohol Action.Biomedicines · 2026Review
- Hypocretin receptor 1 blockade early in abstinence prevents incubation of cocaine seeking and normalizes dopamine transmission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Current approaches using remote monitoring technology in alcohol use disorder (AUD): an integrative review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Review
- Leveraging mHealth and Wearable Sensors to Manage Alcohol Use Disorders: A Systematic Literature Review.Healthcare (Basel, Switzerland) · 2022Review
- Trends in the Use of Naltrexone for Addiction Treatment among Alcohol Use Disorder Admissions in U.S. Substance Use Treatment Facilities.International journal of environmental research and public health · 2021Article
- Research on Smart Healthcare Services: Based on the Design of APP Health Service Platform.Journal of healthcare engineering · 2021Article
- Monitoring and Improving Naltrexone Adherence in Patients with Substance Use Disorder.Patient preference and adherence · 2021Review
- OPRM1 Moderates Daily Associations of Naltrexone Adherence With Alcohol Consumption: Preliminary Evidence From a Mobile Health Trial.Alcoholism, clinical and experimental research · 2020Article
- Adherence Across FDA-Approved Medications for Alcohol Use Disorder in a Veterans Administration Population.Journal of studies on alcohol and drugs · 2019Article
- Technological Interventions for Medication Adherence in Adult Mental Health and Substance Use Disorders: A Systematic Review.JMIR mental health · 2019Article
- Using text message reminders in health care services: A narrative literature review.Internet interventions · 2018Review
- Predictors of Daily Adherence to Naltrexone for Alcohol Use Disorder Treatment During a Mobile Health Intervention.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- The Role of Technology-Based Interventions for Substance Use Disorders in Primary Care: A Review of the Literature.The Medical clinics of North America · 2018Review
- New steps for treating alcohol use disorder.Psychopharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundNaltrexone is a front-line treatment for alcohol use disorders, but its efficacy is limited by poor medication adherence. This randomized controlled trial evaluated whether a mobile health intervention could improve naltrexone adherence.
methodsTreatment-seeking participants with an alcohol use disorder (N = 76) were randomized to intervention and control conditions. All participants received naltrexone (50 mg/day) with a medication event monitoring system (MEMS) and a prepaid smartphone, and received a daily text message querying medication side effects, alcohol use, and craving. Those in the intervention arm received additional medication reminders and adherence assessment via text message.
resultsThe primary outcome, proportion of participants with adequate adherence (defined as ≥80% of prescribed doses taken through Week 8), did not differ between groups in intent-to-treat analyses (p = .34). Mean adherence at study midpoint (Week 4) was 83% in the intervention condition and 77% in the control condition (p = .35). Survival analysis found that the intervention group sustained adequate adherence significantly longer (M = 19 days [95% CI = 0.0-44.0]) than those in the control group (M = 3 days [95% CI = 0.0-8.1]) during the first month of treatment (p = .04). Medication adherence did not predict drinking outcomes.
conclusionsThese results suggest that in the context of daily monitoring and assessment via cell phone, additional text message reminders do not further improve medication adherence. Although this initial trial does not provide support for the efficacy of text messaging to improve adherence to pharmacotherapy for alcohol use disorders, additional trials with larger samples and alternate designs are warranted.
trial registrationClinicalTrials.gov: NCT01349985.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.