Evidence map›Paper›PMID 25909030›Full record

ArticleBiomedical optics express2015

Measuring the optical characteristics of medulloblastoma with optical coherence tomography.

Barry Vuong, Patryk Skowron, Tim-Rasmus Kiehl, Matthew Kyan, Livia Garzia, Cuiru Sun, Michael D Taylor, Victor X D Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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  8. Retinoblastoma, the visible CNS tumor: A review.Journal of neuroscience research · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Barry VuongBiophotonics and Bioengineering Laboratory, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada ; Department of Electrical and Computer Engineering, Ryerson University, 350 Victoria St., Toronto, M4B 2K3, Canada.
Patryk SkowronBiophotonics and Bioengineering Laboratory, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada ; Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, 686 Bay Street, Toronto, M5G 1L7, Canada.
Tim-Rasmus KiehlUniversiy Health Network, Department of Pathology, 190 Elizabeth St., Toronto, M5G 2C4, Canada ; University of Toronto, Department of Laboratory Medicine and Pathobiology, 172 St George St, Toronto, M5R 0A3, Canada.
Matthew KyanDepartment of Electrical and Computer Engineering, Ryerson University, 350 Victoria St., Toronto, M4B 2K3, Canada.
Livia GarziaHospital for Sick Children, Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, 686 Bay Street, Toronto, M5G 1L7, Canada ; Hospital for Sick Children,Program in Developmental and Stem Cell Biology, 555 University Avenue, Toronto, M5G 1X8, Canada ; University of Toronto, Department of Laboratory Medicine and Pathobiology, 1 King's College Circle, Toronto, M5S 1A8, Canada.
Cuiru SunBiophotonics and Bioengineering Laboratory, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.
Michael D TaylorDepartment of Electrical and Computer Engineering, Ryerson University, 350 Victoria St., Toronto, M4B 2K3, Canada ; Hospital for Sick Children,Program in Developmental and Stem Cell Biology, 555 University Avenue, Toronto, M5G 1X8, Canada ; University of Toronto, Department of Laboratory Medicine and Pathobiology, 1 King's College Circle, Toronto, M5S 1A8, Canada ; Division of Neurosurgery, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Victor X D YangBiophotonics and Bioengineering Laboratory, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada ; Division of Neurosurgery, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada ; Physical Science - Brain Sciences Research Program, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada ; Division of Neurosurgery, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue Toronto, ON, M4N 3M5, Canada.
Toronto Metropolitan University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medulloblastoma is the most common malignant pediatric brain tumor. Standard treatment consists of surgical resection, followed by radiation and high-dose chemotherapy. Despite these efforts, recurrence is common, leading to reduced patient survival. Even with successful treatment, there are often severe long-term neurologic impacts on the developing nervous system. We present two quantitative techniques that use a high-resolution optical imaging modality: optical coherence tomography (OCT) to measure refractive index, and the optical attenuation coefficient. To the best of our knowledge, this study is the first to demonstrate OCT analysis of medulloblastoma. Refractive index and optical attenuation coefficient were able to differentiate between normal brain tissue and medulloblastoma in mouse models. More specifically, optical attenuation coefficient imaging of normal cerebellum displayed layers of grey matter and white matter, which were indistinguishable in the structural OCT image. The morphology of the tumor was distinct in the optical attenuation coefficient imaging. These inherent properties may be useful during neurosurgical intervention to better delineate tumor boundaries and minimize resection of normal tissue.

Indexed as

(100.2960) Image analysis(110.4500) Optical coherence tomography(170.6935) Tissue characterization(290.1350) Backscattering

Identifiers

PMID25909030
PMCPMC4399685
OpenAlexW2088910319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.