ArticleBiomedical optics express2015
Quantitative microvascular hemoglobin mapping using visible light spectroscopic Optical Coherence Tomography.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Ultrabroadband OCT for simultaneous visible and near-infrared light imaging of the mouse retina.Biomedical optics express · 2026Article
- Combined Mouse Retinal Optoretinography/Electroretinography System to Study Light-Evoked Responses in Animal Models of Retinal Degeneration.Investigative ophthalmology & visual science · 2026Article
- Assessing and monitoring abnormal retinal blood circulation for early detection of pre-structural damage and enhanced diabetic retinopathy staging using non-invasive, high-resolution biophotonic imaging technology.Eye (London, England) · 2025Review
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Balanced-detection visible optical coherence tomography with a low-noise supercontinuum laser.Biomedical optics express · 2025Article
- Article
- Visible light optical coherence tomography for assessing retinal structure and function in diseased mouse models.Biomedical optics express · 2025Article
- Phase-restoring subpixel image registration: enhancing motion detection performance in Fourier-domain optical coherence tomography.Journal of physics D: Applied physics · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Non-invasive quantification of total hemoglobin concentrations by visible-light spectroscopic optical coherence tomography: a validation study on healthy volunteers.Biomedical optics express · 2025Article
- Depth-gated Fourier transform to accelerate spectral recovery in visible light optical coherence tomography retinal oximetry.Optics letters · 2025Article
- On-axis full-field swept-source optical coherence tomography for murine retinal imaging.Optics letters · 2024Article
- Quantitative Optical Imaging of Oxygen in Brain Vasculature.The journal of physical chemistry. B · 2024Review
- Bichromatic tetraphasic full-field optical coherence microscopy.Journal of biomedical optics · 2024Article
- Deep learning network for parallel self-denoising and segmentation in visible light optical coherence tomography of the human retina.Biomedical optics express · 2023Article
- Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography.Biomedical optics express · 2023Article
- Imaging human macular pigments with visible light optical coherence tomography and superluminescent diodes.Optics letters · 2023Article
- Adaptive spectroscopic visible-light optical coherence tomography for clinical retinal oximetry.Communications medicine · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Quantification of chromophore concentrations in reflectance mode remains a major challenge for biomedical optics. Spectroscopic Optical Coherence Tomography (SOCT) provides depth-resolved spectroscopic information necessary for quantitative analysis of chromophores, like hemoglobin, but conventional SOCT analysis methods are applicable only to well-defined specular reflections, which may be absent in highly scattering biological tissue. Here, by fitting of the dynamic scattering signal spectrum in the OCT angiogram using a forward model of light propagation, we quantitatively determine hemoglobin concentrations directly. Importantly, this methodology enables mapping of both oxygen saturation and total hemoglobin concentration, or alternatively, oxyhemoglobin and deoxyhemoglobin concentration, simultaneously. Quantification was verified by ex vivo blood measurements at various pO2 and hematocrit levels. Imaging results from the rodent brain and retina are presented. Confounds including noise and scattering, as well as potential clinical applications, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.