ArticleBiomedical optics express2015
Ex vivo catheter-based imaging of coronary atherosclerosis using multimodality OCT and NIRAF excited at 633 nm.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Computational Analysis of Intravascular OCT Images for Future Clinical Support: A Comprehensive Review.IEEE reviews in biomedical engineering · 2026Review
- Identification and removal of system-induced autofluorescence in miniaturized fiber-optic fluorescence endoscopes.PNAS nexus · 2025Article
- Invasive coronary imaging of inflammation to further characterize high-risk lesions: what options do we have?Frontiers in cardiovascular medicine · 2024Review
- Combined near infrared photoacoustic imaging and ultrasound detects vulnerable atherosclerotic plaque.Biomaterials · 2023Article
- Significance of Intra-plaque Hemorrhage for the Development of High-Risk Vulnerable Plaque: Current Understanding from Basic to Clinical Points of View.International journal of molecular sciences · 2023Review
- Imaging Techniques in Pharmacological Precision Medicine.Handbook of experimental pharmacology · 2023Article
- Histopathological correlation of near infrared autofluorescence in human cadaver coronary arteries.Atherosclerosis · 2022Article
- Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications.Biosensors · 2022Review
- Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy.Biomedical optics express · 2021Article
- Near-Infrared Autofluorescence in Atherosclerosis Associates With Ceroid and Is Generated by Oxidized Lipid-Induced Oxidative Stress.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model.Biomedical optics express · 2018Article
- Intravascular Photothermal Strain Imaging for Lipid Detection.Sensors (Basel, Switzerland) · 2018Article
- Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging.Scientific reports · 2018Article
- PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis.Current cardiology reports · 2018Review
- In vivo label-free structural and biochemical imaging of coronary arteries using an integrated ultrasound and multispectral fluorescence lifetime catheter system.Scientific reports · 2017Article
- Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.Nature communications · 2017Article
- Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology.European heart journal · 2017Review
- Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging.JACC. Cardiovascular imaging · 2016Article
- Imaging: Focusing light on the vulnerable plaque.Nature reviews. Cardiology · 2016Article
- Intravascular NIRF Molecular Imaging Approaches in Coronary Artery Disease.Current cardiovascular imaging reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
While optical coherence tomography (OCT) has been shown to be capable of imaging coronary plaque microstructure, additional chemical/molecular information may be needed in order to determine which lesions are at risk of causing an acute coronary event. In this study, we used a recently developed imaging system and double-clad fiber (DCF) catheter capable of simultaneously acquiring both OCT and red excited near-infrared autofluorescence (NIRAF) images (excitation: 633 nm, emission: 680nm to 900nm). We found that NIRAF is elevated in lesions that contain necrotic core - a feature that is critical for vulnerable plaque diagnosis and that is not readily discriminated by OCT alone. We first utilized a DCF ball lens probe and a bench top setup to acquire en face NIRAF images of aortic plaques ex vivo (n = 20). In addition, we used the OCT-NIRAF system and fully assembled catheters to acquire multimodality images from human coronary arteries (n = 15) prosected from human cadaver hearts (n = 5). Comparison of these images with corresponding histology demonstrated that necrotic core plaques exhibited significantly higher NIRAF intensity than other plaque types. These results suggest that multimodality intracoronary OCT-NIRAF imaging technology may be used in the future to provide improved characterization of coronary artery disease in human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.