ArticleBiomedical optics express2015
High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Label-free viability assessment ofBiomedical optics express · 2026Article
- Stretched-Pulse Mode-Locked Laser Using Post-Cavity Stretching for Ultrahigh-Speed OCT.IEEE photonics technology letters : a publication of the IEEE Laser and Electro-optics Society · 2025Article
- Reconstruction of Optical Coherence Tomography Images from Wavelength Space Using Deep Learning.Sensors (Basel, Switzerland) · 2024Article
- Microscope integrated MHz optical coherence tomography system for neurosurgery: development and clinical in-vivo imaging.Biomedical optics express · 2024Article
- Article
- Dual-modality imaging system for monitoring human heart organoids beating in vitro.Optics letters · 2023Article
- Fourier Domain Mode Locked Laser and Its Applications.Sensors (Basel, Switzerland) · 2022Review
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes.Biomedical optics express · 2021Article
- 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking.Scientific reports · 2020Article
- High-resolution wide-field OCT angiography with a self-navigation method to correct microsaccades and blinks.Biomedical optics express · 2020Article
- Evaluating changes of blood flow in retina, choroid, and outer choroid in rats in response to elevated intraocular pressure by 1300 nm swept-source OCT.Microvascular research · 2019Article
- High-throughput imaging flow cytometry by optofluidic time-stretch microscopy.Nature protocols · 2018Article
- Phase-stable Doppler OCT at 19 MHz using a stretched-pulse mode-locked laser.Biomedical optics express · 2018Article
- High-speed optical coherence tomography by circular interferometric ranging.Nature photonics · 2018Article
- Long ranging swept-source optical coherence tomography-based angiography outperforms its spectral-domain counterpart in imaging human skin microcirculations.Journal of biomedical optics · 2017Article
- Optical coherence tomography angiography-based capillary velocimetry.Journal of biomedical optics · 2017Article
- VCSEL-based swept source for low-cost optical coherence tomography.Biomedical optics express · 2017Article
- High-speed OCT light sources and systems [Invited].Biomedical optics express · 2017Review
- Wide field and highly sensitive angiography based on optical coherence tomography with akinetic swept source.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the key prerequisite of high-speed volumetric structural and functional tissue imaging in real-time, scaling the A-scan rate beyond MHz has been one of the major pursuits in the development of optical coherence tomography (OCT). Along with a handful of techniques enabling multi-MHz, amplified optical time-stretch OCT (AOT-OCT) has recently been demonstrated as a viable alternative for ultrafast swept-source OCT well above MHz without the need for the mechanical wavelength-tuning mechanism. In this paper, we report a new generation of AOT-OCT demonstrating superior performance to its older generation and all other time-stretch-based OCT modalities in terms of shot-to-shot stability, sensitivity (~90dB), roll-off performance (>4 mm/dB) and A-scan rate (11.5 MHz). Such performance is mainly attributed to the combined contribution from the stable operation of the broadband and compact mode-locked fiber laser as well as the optical amplification in-line with the time-stretch process. The system allows us, for the first time, to deliver volumetric time-stretch-based OCT of biological tissues with the single-shot A-scan rate beyond 10 MHz. Comparing with the existing high-speed OCT systems, the inertia-free AOT-OCT shows promises to realize high-performance 3D OCT imaging at video rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.