ArticleBiomedical optics express2015
Characterizing the beam steering and distortion of Gaussian and Bessel beams focused in tissues with microscopic heterogeneities.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis.Biomedical optics express · 2025Article
- Miniature line-scanned dual-axis confocal microscope for versatile clinical use.Biomedical optics express · 2023Article
- Miniature side-view dual axes confocal endomicroscope for repetitive in vivo imaging.Biomedical optics express · 2023Article
- In vivo volumetric imaging of calcium and glutamate activity at synapses with high spatiotemporal resolution.Nature communications · 2021Article
- Three-Dimensional Single-Molecule Localization Microscopy in Whole-Cell and Tissue Specimens.Annual review of biomedical engineering · 2020Review
- Depth-extended, high-resolution fluorescence microscopy: whole-cell imaging with double-ring phase (DRiP) modulation.Biomedical optics express · 2019Article
- Light-sheet microscopy with attenuation-compensated propagation-invariant beams.Science advances · 2018Article
- Bessel-beam illumination in dual-axis confocal microscopy mitigates resolution degradation caused by refractive heterogeneities.Journal of biophotonics · 2017Article
- Enhancement of image quality and imaging depth with Airy light-sheet microscopy in cleared and non-cleared neural tissue.Biomedical optics express · 2016Article
- Assessing the imaging performance of light sheet microscopies in highly scattering tissues.Biomedical optics express · 2016Article
- Fractal propagation method enables realistic optical microscopy simulations in biological tissues.Optica · 2016Article
- Dual-axis confocal microscopy for point-of-care pathology.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics SocietyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bessel beams have recently been investigated as a means of improving deep-tissue microscopy in highly scattering and heterogeneous media. It has been suggested that the long depth-of-field and self-reconstructing property of a Bessel beam enables an increased penetration depth of the focused beam in tissues compared to a conventional Gaussian beam. However, a study is needed to better quantify the magnitude of the beam steering as well as the distortion of focused Gaussian and Bessel beams in tissues with microscopic heterogeneities. Here, we have developed an imaging method and quantitative metrics to evaluate the motion and distortion of low-numerical-aperture (NA) Gaussian and Bessel beams focused in water, heterogeneous phantoms, and fresh mouse esophagus tissues. Our results indicate that low-NA Bessel beams exhibit reduced beam-steering artifacts and distortions compared to Gaussian beams, and are therefore potentially useful for microscopy applications in which pointing accuracy and beam quality are critical, such as dual-axis confocal (DAC) microscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.