Evidence map›Paper›PMID 25909001›Full record

ArticleBiomedical optics express2015

Ultrahigh speed en face OCT capsule for endoscopic imaging.

Kaicheng Liang, Giovanni Traverso, Hsiang-Chieh Lee, Osman Oguz Ahsen, Zhao Wang, Benjamin Potsaid, Michael Giacomelli, Vijaysekhar Jayaraman, Ross Barman, Alex Cable and 3 more

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Article
  10. Feasibility and Safety of Tethered Capsule Endomicroscopy in Patients With Barrett's Esophagus in a Multi-Center Study.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  11. EndoscopicBiomedical optics express · 2022
    Article
  12. Optical coherence tomography.Nature reviews. Methods primers · 2022
    Article
  13. Capsule Endoscopy: Pitfalls and Approaches to Overcome.Diagnostics (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kaicheng LiangDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Giovanni TraversoKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA ; Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA ; Harvard Medical School, Boston MA, USA.
Hsiang-Chieh LeeDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Osman Oguz AhsenDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Zhao WangDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Benjamin PotsaidDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA ; Advanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
Michael GiacomelliDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Vijaysekhar JayaramanPraevium Research Inc., Santa Barbara CA, USA.
Ross BarmanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA.
Alex CableAdvanced Imaging Group, Thorlabs Inc., Newton NJ, USA.
Hiroshi MashimoHarvard Medical School, Boston MA, USA ; Veterans Affairs Boston Healthcare System, Boston MA, USA.
Robert LangerKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA, USA ; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge MA, USA.
James G FujimotoDepartment of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge MA, USA.
Massachusetts Institute of Technology · USPraevium Research (United States) · US

Funding

RESEARCH TRAINING IN DIGESTIVE DISEASES AND NUTRITIONT32DK007191 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1986 to 2026
$14.6M
Novel Optical Diagnostics with Optical Coherence TomographyR01EY011289 · NEI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI JAMES G FUJIMOTO · 1995 to 2026
$9.5M
OPTICAL BIOPSY USING OPTICAL COHERENCE TOMOGRAPHYR01CA075289 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FUJIMOTO, JAMES G, MASHIMO, HIROSHI · 1997 to 2018
$4.8M
Controlled Release of MacromoleculesR37EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2008 to 2017
$3.9M
Ultrahigh speed and resolution OCT/OCM using broadband swept VCSEL technologyR44CA101067 · NCI · PRAEVIUM RESEARCH, INC. · PI JAYARAMAN, VIJAYSEKHAR · 2003 to 2012
$2.9M
Intraoperative real time breast cancer margin assessment with nonlinear microscopR01CA178636 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CONNOLLY, JAMES, FUJIMOTO, JAMES G · 2013 to 2018
$1.7M
VCSEL technology for ultrahigh speed OCT retinal and anterior eye imagingR44EY022864 · NEI · PRAEVIUM RESEARCH, INC. · PI JAYARAMAN, VIJAYSEKHAR · 2012 to 2014
$1.1M
NCI NIH HHS R01 CA075289NCI NIH HHS R01 CA178636NCI NIH HHS R44 CA101067NEI NIH HHS R01 EY011289NEI NIH HHS R44 EY022864NIBIB NIH HHS R37 EB000244NIDDK NIH HHS T32 DK007191
6 · The paper itself

Abstract

Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or advancing the capsule while scanning the distal high-speed micromotor. Circumferential en face OCT was demonstrated in living swine at 250 Hz frame rate and 1 MHz A-scan rate using a MEMS tunable VCSEL light source at 1300 nm. Cross-sectional and en face OCT views of the upper and lower gastrointestinal tract were generated with precision distal pneumatic longitudinal actuation as well as proximal manual longitudinal actuation. These devices could enable clinical studies either as an adjunct to endoscopy, attached to an endoscope, or as a swallowed tethered capsule for non-endoscopic imaging without sedation. The combination of ultrahigh speed imaging and distal scanning capsule technology could enable both screening and surveillance applications.

Indexed as

(170.2150) Endoscopic imaging(170.2680) Gastrointestinal(170.3880) Medical and biological imaging(170.4500) Optical coherence tomography

Identifiers

PMID25909001
PMCPMC4399656
OpenAlexW1978939333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.